Disease relevance of NTH2

• In the present paper, we have analysed the expression of the trehalase genes under heat stress conditions and present genetic evidence for the 'poor-heat-shock-recovery' phenotype associated with NTH1 and YBR0106 mutants [1].

High impact information on NTH2

• We therefore propose that the NTH1 and NTH2 genes have stress-related function and the gene products may be called stress proteins [2].
• The role of the putative trehalase Nth2p in trehalose metabolism is not known [2].
• YLR345Wp and NTH2p are enzymes involved in the central metabolism under stress conditions [3].
• However, similar to the NTH1 gene a requirement of the intact YBR0106 gene for thermotolerance is demonstrated in experiments with the respective mutants [4].
• The trehalase gene (YBR0106) on chromosome II is located beside the centromere and transcribed towards it [5].

Biological context of NTH2

• A gene with 77% identity with NTH1, YBR0106, which was discovered during sequencing of chromosome II (Wolfe, K. H., and Lohan, A. J. E. (1994) Yeast 10, S41-S46), is shown here to be expressed into mRNA [4].
• The YBR0106 and NTH1 proteins are 77% identical in predicted amino acid sequence, but there is no pronounced sequence similarity between the two centromeres (CEN2 and CEN4) outside of the universally conserved CDE I and CDE III elements [5].

Other interactions of NTH2

• We determined trehalose, nitrogen, sugar consumption and expression of NTH1, NTH2 and TPS1 [6].

References