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Gene Review

NTH2  -  alpha,alpha-trehalase NTH2

Saccharomyces cerevisiae S288c

Synonyms: Alpha,alpha-trehalase, Alpha,alpha-trehalose glucohydrolase, YBR001C, YBR0106
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Disease relevance of NTH2

  • In the present paper, we have analysed the expression of the trehalase genes under heat stress conditions and present genetic evidence for the 'poor-heat-shock-recovery' phenotype associated with NTH1 and YBR0106 mutants [1].

High impact information on NTH2

  • We therefore propose that the NTH1 and NTH2 genes have stress-related function and the gene products may be called stress proteins [2].
  • The role of the putative trehalase Nth2p in trehalose metabolism is not known [2].
  • YLR345Wp and NTH2p are enzymes involved in the central metabolism under stress conditions [3].
  • However, similar to the NTH1 gene a requirement of the intact YBR0106 gene for thermotolerance is demonstrated in experiments with the respective mutants [4].
  • The trehalase gene (YBR0106) on chromosome II is located beside the centromere and transcribed towards it [5].

Biological context of NTH2

  • A gene with 77% identity with NTH1, YBR0106, which was discovered during sequencing of chromosome II (Wolfe, K. H., and Lohan, A. J. E. (1994) Yeast 10, S41-S46), is shown here to be expressed into mRNA [4].
  • The YBR0106 and NTH1 proteins are 77% identical in predicted amino acid sequence, but there is no pronounced sequence similarity between the two centromeres (CEN2 and CEN4) outside of the universally conserved CDE I and CDE III elements [5].

Other interactions of NTH2


  1. Phenotypic features of trehalase mutants in Saccharomyces cerevisiae. Nwaka, S., Mechler, B., Destruelle, M., Holzer, H. FEBS Lett. (1995) [Pubmed]
  2. Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae. Nwaka, S., Holzer, H. Prog. Nucleic Acid Res. Mol. Biol. (1998) [Pubmed]
  3. Identification of new genes regulated by the Crt1 transcription factor, an effector of the DNA damage checkpoint pathway in Saccharomyces cerevisiae. Zaim, J., Speina, E., Kierzek, A.M. J. Biol. Chem. (2005) [Pubmed]
  4. Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. Nwaka, S., Kopp, M., Holzer, H. J. Biol. Chem. (1995) [Pubmed]
  5. Sequence around the centromere of Saccharomyces cerevisiae chromosome II: similarity of CEN2 to CEN4. Wolfe, K.H., Lohan, A.J. Yeast (1994) [Pubmed]
  6. Effect of nitrogen limitation and surplus upon trehalose metabolism in wine yeast. Novo, M.T., Beltran, G., Rozès, N., Guillamón, J.M., Mas, A. Appl. Microbiol. Biotechnol. (2005) [Pubmed]
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