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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PCH2  -  Pch2p

Saccharomyces cerevisiae S288c

Synonyms: Pachytene checkpoint protein 2, YBR1308, YBR186W
 
 
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High impact information on PCH2

  • The PCH2 gene of Saccharomyces cerevisiae is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective [1].
  • Under certain circumstances, Sir3-dependent localization of Pch2 to telomeres also provides checkpoint function [1].
  • Most of the Pch2 protein localizes to the nucleolus, where it represses meiotic interhomolog recombination in the ribosomal DNA, apparently by excluding the meiosis-specific Hop1 protein [1].
  • A PCH2-ZIP1-dependent checkpoint in meiosis is likely conserved among synaptic organisms from yeast to human [2].
  • In dot1, disruption of the checkpoint correlates with the loss of concentration of Pch2 and Sir2 in the nucleolus [3].
 

Biological context of PCH2

  • Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved [4].

References

  1. Pch2 links chromatin silencing to meiotic checkpoint control. San-Segundo, P.A., Roeder, G.S. Cell (1999) [Pubmed]
  2. Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in budding yeast. Wu, H.Y., Burgess, S.M. Curr. Biol. (2006) [Pubmed]
  3. Role for the silencing protein Dot1 in meiotic checkpoint control. San-Segundo, P.A., Roeder, G.S. Mol. Biol. Cell (2000) [Pubmed]
  4. A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans. Bhalla, N., Dernburg, A.F. Science (2005) [Pubmed]
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