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Gene Review

PCH2  -  Pch2p

Saccharomyces cerevisiae S288c

Synonyms: Pachytene checkpoint protein 2, YBR1308, YBR186W
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High impact information on PCH2

  • The PCH2 gene of Saccharomyces cerevisiae is required for the meiotic checkpoint that prevents chromosome segregation when recombination and chromosome synapsis are defective [1].
  • Under certain circumstances, Sir3-dependent localization of Pch2 to telomeres also provides checkpoint function [1].
  • Most of the Pch2 protein localizes to the nucleolus, where it represses meiotic interhomolog recombination in the ribosomal DNA, apparently by excluding the meiosis-specific Hop1 protein [1].
  • A PCH2-ZIP1-dependent checkpoint in meiosis is likely conserved among synaptic organisms from yeast to human [2].
  • In dot1, disruption of the checkpoint correlates with the loss of concentration of Pch2 and Sir2 in the nucleolus [3].

Biological context of PCH2

  • Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved [4].


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