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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans.

We report the discovery of a checkpoint that monitors synapsis between homologous chromosomes to ensure accurate meiotic segregation. Oocytes containing unsynapsed chromosomes selectively undergo apoptosis even if a germline DNA damage checkpoint is inactivated. This culling mechanism is specifically activated by unsynapsed pairing centers, cis-acting chromosome sites that are also required to promote synapsis in Caenorhabditis elegans. Apoptosis due to synaptic failure also requires the C. elegans homolog of PCH2, a budding yeast pachytene checkpoint gene, which suggests that this surveillance mechanism is widely conserved.[1]

References

  1. A conserved checkpoint monitors meiotic chromosome synapsis in Caenorhabditis elegans. Bhalla, N., Dernburg, A.F. Science (2005) [Pubmed]
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