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Gene Review

MCM7  -  mini-chromosome maintenance complex protein 7

Saccharomyces cerevisiae S288c

Synonyms: CDC47, Cell division control protein 47, DNA replication licensing factor MCM7, Minichromosome maintenance protein 7, YBR1441, ...
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High impact information on CDC47


Biological context of CDC47


Physical interactions of CDC47

  • The assembly of Cdc47p into complexes with Cdc46p does not appear to be cell cycle regulated, making it unlikely that these interactions per se are a rate-limiting step in the control of S phase [3].
  • Cdc45p is also shown to interact with Cdc47p in vivo and to be a component of high-molecular-weight MCM complexes in cell lysates [3].

Other interactions of CDC47

  • We characterize two mutations in CDC47 and CDC46 which arrest cells with unduplicated DNA as a result of single base substitutions [3].
  • Characterization of Cdc47p-minichromosome maintenance complexes in Saccharomyces cerevisiae: identification of Cdc45p as a subunit [3].

Analytical, diagnostic and therapeutic context of CDC47

  • Using indirect immunofluorescence microscopy and subcellular fractionation techniques, we show that Cdc47 undergoes cell cycle-regulated changes in its subcellular localization [2].


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