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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NBP35  -  Nbp35p

Saccharomyces cerevisiae S288c

Synonyms: Cytosolic Fe-S cluster assembly factor NBP35, Nucleotide-binding protein 35, YGL091C
 
 
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Disease relevance of NBP35

 

High impact information on NBP35

  • Moreover, defects in the de novo maturation of various cytosolic and nuclear Fe/S proteins were observed in the absence of Nbp35p, demonstrating the functional involvement of Nbp35p in the biogenesis of extramitochondrial Fe/S proteins [2].
  • The assembly of cytosolic and nuclear iron-sulfur (Fe/S) proteins in yeast is dependent on the iron-sulfur cluster assembly and export machineries in mitochondria and three recently identified extramitochondrial proteins, the P-loop NTPases Cfd1 and Nbp35 and the hydrogenase-like Nar1 [3].
  • A single amino-acid substitution in the conserved nucleotide-binding motif of Nbp35p renders the protein non-functional [1].
  • Sequence analysis revealed structural homology of Nbp35p with a family of bacterial ATPases involved in cell division processes and chromosome partitioning [1].
 

Associations of NBP35 with chemical compounds

  • Using in vivo and in vitro approaches, we found that the soluble P-loop NTPases Cfd1 and Nbp35 form a complex and bind up to three [4Fe-4S] clusters, one at the N terminus of Nbp35 and one each at a new C-terminal cysteine-rich motif present in both proteins [4].
 

Other interactions of NBP35

  • In contrast, repression of NAR1, CFD1, or NBP35 fails to induce the iron regulon despite strong inhibition of cytosolic/nuclear Fe-S protein assembly [5].

References

  1. NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases. Vitale, G., Fabre, E., Hurt, E.C. Gene (1996) [Pubmed]
  2. The eukaryotic P loop NTPase Nbp35: an essential component of the cytosolic and nuclear iron-sulfur protein assembly machinery. Hausmann, A., Aguilar Netz, D.J., Balk, J., Pierik, A.J., Mühlenhoff, U., Lill, R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Balk, J., Aguilar Netz, D.J., Tepper, K., Pierik, A.J., Lill, R. Mol. Cell. Biol. (2005) [Pubmed]
  4. The Cfd1-Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol. Netz, D.J., Pierik, A.J., Stümpfig, M., Mühlenhoff, U., Lill, R. Nat. Chem. Biol. (2007) [Pubmed]
  5. Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. Rutherford, J.C., Ojeda, L., Balk, J., Mühlenhoff, U., Lill, R., Winge, D.R. J. Biol. Chem. (2005) [Pubmed]
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