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Gene Review

NUBP1  -  nucleotide binding protein 1

Homo sapiens

Synonyms: Cytosolic Fe-S cluster assembly factor NUBP1, NBP, NBP 1, NBP1, NBP35, ...
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Disease relevance of NUBP1

  • A novel human cDNA encoding a putative nucleotide-binding protein (NBP) was obtained by screening a human SHSY5Y neuroblastoma library [1].
  • Forearm vascular resistance (FVR) fell by 35 +/- 21% in exercise-induced hypotension patients versus an increase of 78 +/- 65% in patients with an NBP response (P < .0001) [2].
  • Recently, we have identified two cellular protein complexes (NBP and UBP) that bind to a region of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) previously shown to contain at least two negative regulatory elements (NREs) termed the promoter-proximal and promoter-distal NREs [3].
  • All patients (four of four) in the NBP group who underwent occlusion lasting 10 minutes or longer suffered an infarction versus five of 23 patients in the IVBP group (p < 0.0001) [4].
  • Retroviral NBP might well drive the packaging of the viral RNA as well as improve reverse transcription of the circular virion RNA [5].

Psychiatry related information on NUBP1

  • RESULTS: In the NBPP group, motor skills were diminished and voluntary torque was reduced relative to M-wave amplitude and twitch torque [6].

High impact information on NUBP1

  • NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization [7].
  • These results demonstrate that, besides p73, an additional p53-like protein exists in cells, which is named NBP for non-p53, p53RE binding protein [8].
  • Ten approximately age- and sex-matched patients with documented CAD and normal exercise blood pressure response (NBP) served as control subjects [2].
  • Antibody ablation, distamycin inhibition of binding, renaturation and competition experiments, and tissue distribution data all confirmed that the NBP complex contained SATB1 [3].
  • OBJECTIVE: To determine whether motor unit activation is impaired in patients with persisting disability arising from neonatal brachial plexus palsy (NBPP) [6].

Biological context of NUBP1


Anatomical context of NUBP1

  • The NBP mRNA is approx. 1500 nt in length and is expressed in several human cell lines and in all rat tissues examined, with the highest levels in lung and testis [1].
  • This study tested the hypothesis that the NPA-binding protein (NBP) is associated with the actin cytoskeleton in vitro and that an intact actin cytoskeleton is required for polar auxin transport in vivo [14].
  • In parallel, the linear density of Purkinje cells (NBP) and the percentage of proliferating cells, immunolabeled with BrdU, were also found significantly higher in stressed animals [15].
  • As a result, it was found that macrophages in the early stage of NBP were more activated than macrophages in the chronic stage [16].

Associations of NUBP1 with chemical compounds

  • On average the single-dose CMT regimen produced the greatest effect on survival, on pentobarbital sleep duration and on total NBP reactive species [17].
  • Both CMT regimens increased the plasma concentration time products for CTX-induced metabolites (NBP) by about 1.3 fold (in contrast to a 33% reduction with phenobarbital) [17].
  • James-Noggle plots constructed for ouabain-sensitive excess relaxation rates show the binding for NBP to be even high affinity (greater than 10(3) M-1) but low capacity [18].
  • IFO and side-chain metabolites were analyzed by gas chromatography, the active metabolites by indirect determination of acrolein (ACR) and IFO mustard (IFO-M) with the NBP test [19].
  • Significantly more boys with high BP had low high-density lipoprotein cholesterol compared with boys with NBP (49.4% vs 27.6%) [20].

Analytical, diagnostic and therapeutic context of NUBP1

  • NBP was purified through conventional and DNA affinity chromatography to apparent homogeneity with a prominent polypeptide migrating in between the 43 and 68 kDa positions on a SDS gel [21].
  • BACKGROUND AND PURPOSE: Bone metastases causing neuropathic pain (NBP) have traditionally been treated with fractionated radiotherapy (RT) [22].
  • However, the results of our study showed that, compared with preventing BPP alone, the cost-effectiveness of pneumococcal vaccination increased substantially even when only a small proportion of additional cases of NBPP were prevented [23].
  • New guidelines governing drug preparation ('NBP' standards of preparation) published in Italian Pharmacopoeia (2002, XI Edition) have been mandatory since 2004 and set out rules for proper pharmacy practice applicable also to antineoplastic drug preparations [24].
  • METHODS: A retrospective, case-control study on 497 patients 2 to 18 years of age at the Nemours Weight Management Clinic of duPont Hospital for Children was conducted to compare the prevalence of abnormal plasma lipid levels in overweight children with high BP with overweight children with NBP [20].


  1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. Shahrestanifar, M., Saha, D.P., Scala, L.A., Basu, A., Howells, R.D. Gene (1994) [Pubmed]
  2. Mechanism of exercise hypotension in patients with ischemic heart disease. Role of neurocardiogenically mediated vasodilation. Lele, S.S., Scalia, G., Thomson, H., Macfarlane, D., Wilkinson, D., Stafford, W., Khafagi, F., Frenneaux, M. Circulation (1994) [Pubmed]
  3. The matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression. Liu, J., Bramblett, D., Zhu, Q., Lozano, M., Kobayashi, R., Ross, S.R., Dudley, J.P. Mol. Cell. Biol. (1997) [Pubmed]
  4. Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection. Lavine, S.D., Masri, L.S., Levy, M.L., Giannotta, S.L. J. Neurosurg. (1997) [Pubmed]
  5. Circularization of retroviral genomic RNA and the control of RNA translation, packaging and reverse transcription. Darlix, J.L. Biochimie (1986) [Pubmed]
  6. Developmental apraxia arising from neonatal brachial plexus palsy. Brown, T., Cupido, C., Scarfone, H., Pape, K., Galea, V., McComas, A. Neurology (2000) [Pubmed]
  7. NBP, a protein that specifically binds an enhancer of immunoglobulin gene rearrangement: purification and characterization. Li, M., Morzycka-Wroblewska, E., Desiderio, S.V. Genes Dev. (1989) [Pubmed]
  8. Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53. Zeng, X., Levine, A.J., Lu, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. A kinetic approach to the alkylating potential of carcinogenic lactones. Manso, J.A., Pérez-Prior, M.T., García-Santos, M.d.e.l. .P., Calle, E., Casado, J. Chem. Res. Toxicol. (2005) [Pubmed]
  10. NBP35 encodes an essential and evolutionary conserved protein in Saccharomyces cerevisiae with homology to a superfamily of bacterial ATPases. Vitale, G., Fabre, E., Hurt, E.C. Gene (1996) [Pubmed]
  11. Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation. Philip, P.A., Lewis, L.D., James, C.A., Rogers, H.J. Cancer Chemother. Pharmacol. (1988) [Pubmed]
  12. Successful modules of community hypertension control programs--examples from the German National High Blood Pressure Programme. Hense, H.W. Journal of human hypertension. (1996) [Pubmed]
  13. Differential reactivities of the mono- and di-epoxide of 1,3-butadiene. Bolt, H.M., Capellmann, M., Jelitto, B., Hindermeier, U., Kirkovsky, L.I. Toxicology (1996) [Pubmed]
  14. In vitro and in vivo evidence for actin association of the naphthylphthalamic acid-binding protein from zucchini hypocotyls. Butler, J.H., Hu, S., Brady, S.R., Dixon, M.W., Muday, G.K. Plant J. (1998) [Pubmed]
  15. The effects of prenatal stress on the Purkinje cell neurogenesis. Ulupinar, E., Yucel, F., Ortug, G. Neurotoxicology and teratology. (2006) [Pubmed]
  16. Study of macrophages in prostatic fluid from nonbacterial prostatitis patients. V. Relation between activation of macrophages and stage of prostatitis. Nishimura, T., Terashima, Y., Hattori, T., Satoh, M., Yoshida, K., Akimoto, M. Urologia internationalis. (1991) [Pubmed]
  17. Cimetidine enhancement of cyclophosphamide antitumour activity. Dorr, R.T., Alberts, D.S. Br. J. Cancer (1982) [Pubmed]
  18. 23Na-NMR studies of Na+ interaction with human red cell membranes from normotensives and hypertensives. Ong, R.L., Cheung, H.C. Biophys. Chem. (1986) [Pubmed]
  19. Excretion kinetics of ifosfamide side-chain metabolites in children on continuous and short-term infusion. Silies, H., Blaschke, G., Hohenlöchter, B., Rossi, R., Jürgens, H., Boos, J. International journal of clinical pharmacology and therapeutics. (1998) [Pubmed]
  20. Effect of obesity and high blood pressure on plasma lipid levels in children and adolescents. Boyd, G.S., Koenigsberg, J., Falkner, B., Gidding, S., Hassink, S. Pediatrics (2005) [Pubmed]
  21. NBP is the p53 homolog p63. Zeng, X., Zhu, Y., Lu, H. Carcinogenesis (2001) [Pubmed]
  22. Costing the components of pain management: analysis of Trans-Tasman Radiation Oncology Group trial (TROG 96.05): one versus five fractions for neuropathic bone pain. Pollicino, C.A., Turner, S.L., Roos, D.E., O'Brien, P.C. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (2005) [Pubmed]
  23. Pneumococcal vaccination and pneumonia: even a low level of clinical effectiveness is highly cost-effective. Ament, A., Fedson, D.S., Christie, P. Clin. Infect. Dis. (2001) [Pubmed]
  24. A centralized Pharmacy Unit for cytotoxic drugs in accordance with Italian legislation. Baldo, P., Bertola, A., Basaglia, G., Moneghini, M., Sorio, R., Zibardi, E., Lazzarini, R., De Paoli, P. Journal of evaluation in clinical practice (2007) [Pubmed]
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