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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NAR1  -  Nar1p

Saccharomyces cerevisiae S288c

Synonyms: Cytosolic Fe-S cluster assembly factor NAR1, N1114, Nuclear architecture-related protein 1, YNL240C
 
 
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High impact information on NAR1

  • In genetic screens for ribosomal export mutants, we identified CFD1, NBP35 and NAR1 as factors involved in ribosome biogenesis [1].
  • In particular, Nar1 was implicated to generate the Fe-S clusters within Rli1, a potential substrate protein of unknown function [1].
  • The genome of the yeast Saccharomyces cerevisiae encodes the essential protein Nar1p that is conserved in virtually all eukaryotes and exhibits striking sequence similarity to bacterial iron-only hydrogenases [2].
  • Here, we demonstrate that Nar1p is predominantly located in the cytosol and contains two adjacent iron-sulphur (Fe/S) clusters [2].
  • Nar1p-depleted cells do not accumulate iron in mitochondria, distinguishing these cells from mutants in components of the mitochondrial Fe/S cluster biosynthesis apparatus [2].
 

Other interactions of NAR1

  • Coimmunoprecipitation assays demonstrated a specific interaction between Cia1 and Nar1 [3].
  • Taken together, our results indicate that Cia1 is a new member of the cytosolic Fe/S protein assembly (CIA) machinery participating in a step after Nbp35 and Nar1 [3].

References

  1. Functional link between ribosome formation and biogenesis of iron-sulfur proteins. Yarunin, A., Panse, V.G., Petfalski, E., Dez, C., Tollervey, D., Hurt, E.C. EMBO J. (2005) [Pubmed]
  2. The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins. Balk, J., Pierik, A.J., Netz, D.J., Mühlenhoff, U., Lill, R. EMBO J. (2004) [Pubmed]
  3. The essential WD40 protein Cia1 is involved in a late step of cytosolic and nuclear iron-sulfur protein assembly. Balk, J., Aguilar Netz, D.J., Tepper, K., Pierik, A.J., Lill, R. Mol. Cell. Biol. (2005) [Pubmed]
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