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AXL2  -  Axl2p

Saccharomyces cerevisiae S288c

Synonyms: Axial budding pattern protein 2, BUD10, Bud site selection protein 10, SRO4, Suppressor of RHO3 protein 4, ...
 
 
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High impact information on AXL2

  • Bud5 also physically interacts with Axl2/Bud10, a transmembrane glycoprotein, suggesting that a receptor-like transmembrane protein recruits a GDP/GTP exchange factor to connect an intrinsic spatial signal to oriented cell growth [1].
  • Genetic analysis indicates that AXL2 falls into the same epistasis group as BUD3 [2].
  • One such gene, AXL2, has been characterized in detail. axl2 cells are defective in bud site selection in haploid cells and bud in a bipolar fashion [2].
  • Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein [2].
  • Overexpression of AXL2 can partially restore proper bud-site selection to pmt4 mutants [3].
 

Biological context of AXL2

  • Towards the end of the cell cycle, the localization of Bud10p refines to a tight double ring which splits at cytokinesis into two single rings, one in each progeny cell [4].
 

Anatomical context of AXL2

  • We suggest that Axl2p acts as an anchor in the plasma membrane that helps direct new growth components and/or polarity establishment components to the cortical axial budding site [2].
  • Subcellular fractionations confirm that Bud10p is associated with membranes [4].
  • Deletion of ERV14 causes a defect in polarized growth because Axl2p, a transmembrane secretory protein, accumulates in the endoplasmic reticulum and is not delivered to its site of function on the cell surface [5].
  • Clusters of Bud10p at the mother-bud neck formed in response to Bud3p (and possibly to an extracellular cue, such as a component of the cell wall), might facilitate the docking of downstream components that direct polarization of the cytoskeleton [4].
 

Associations of AXL2 with chemical compounds

  • Three of the four known proteins required for axial budding, Bud3p, Bud4p, and Axl2p, were expressed and localized appropriately in glucose-limiting conditions [6].
 

Physical interactions of AXL2

  • Axl2p interacts with Cdc42p and other polarity-establishment proteins, and it regulates septin organization in late G1 independently of its role in polarity-axis determination [7].
 

Other interactions of AXL2

References

  1. A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity. Kang, P.J., Sanson, A., Lee, B., Park, H.O. Science (2001) [Pubmed]
  2. Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Roemer, T., Madden, K., Chang, J., Snyder, M. Genes Dev. (1996) [Pubmed]
  3. O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells. Sanders, S.L., Gentzsch, M., Tanner, W., Herskowitz, I. J. Cell Biol. (1999) [Pubmed]
  4. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme, A., Michelitch, M., Mitchell, E.L., Chant, J. Curr. Biol. (1996) [Pubmed]
  5. Erv14p directs a transmembrane secretory protein into COPII-coated transport vesicles. Powers, J., Barlowe, C. Mol. Biol. Cell (2002) [Pubmed]
  6. The roles of bud-site-selection proteins during haploid invasive growth in yeast. Cullen, P.J., Sprague, G.F. Mol. Biol. Cell (2002) [Pubmed]
  7. Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Gao, X.D., Sperber, L.M., Kane, S.A., Tong, Z., Tong, A.H., Boone, C., Bi, E. Mol. Biol. Cell (2007) [Pubmed]
 
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