The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AXL2  -  Axl2p

Saccharomyces cerevisiae S288c

Synonyms: Axial budding pattern protein 2, BUD10, Bud site selection protein 10, SRO4, Suppressor of RHO3 protein 4, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AXL2

  • Bud5 also physically interacts with Axl2/Bud10, a transmembrane glycoprotein, suggesting that a receptor-like transmembrane protein recruits a GDP/GTP exchange factor to connect an intrinsic spatial signal to oriented cell growth [1].
  • Genetic analysis indicates that AXL2 falls into the same epistasis group as BUD3 [2].
  • One such gene, AXL2, has been characterized in detail. axl2 cells are defective in bud site selection in haploid cells and bud in a bipolar fashion [2].
  • Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein [2].
  • Overexpression of AXL2 can partially restore proper bud-site selection to pmt4 mutants [3].

Biological context of AXL2

  • Towards the end of the cell cycle, the localization of Bud10p refines to a tight double ring which splits at cytokinesis into two single rings, one in each progeny cell [4].

Anatomical context of AXL2

  • We suggest that Axl2p acts as an anchor in the plasma membrane that helps direct new growth components and/or polarity establishment components to the cortical axial budding site [2].
  • Subcellular fractionations confirm that Bud10p is associated with membranes [4].
  • Deletion of ERV14 causes a defect in polarized growth because Axl2p, a transmembrane secretory protein, accumulates in the endoplasmic reticulum and is not delivered to its site of function on the cell surface [5].
  • Clusters of Bud10p at the mother-bud neck formed in response to Bud3p (and possibly to an extracellular cue, such as a component of the cell wall), might facilitate the docking of downstream components that direct polarization of the cytoskeleton [4].

Associations of AXL2 with chemical compounds

  • Three of the four known proteins required for axial budding, Bud3p, Bud4p, and Axl2p, were expressed and localized appropriately in glucose-limiting conditions [6].

Physical interactions of AXL2

  • Axl2p interacts with Cdc42p and other polarity-establishment proteins, and it regulates septin organization in late G1 independently of its role in polarity-axis determination [7].

Other interactions of AXL2


  1. A GDP/GTP exchange factor involved in linking a spatial landmark to cell polarity. Kang, P.J., Sanson, A., Lee, B., Park, H.O. Science (2001) [Pubmed]
  2. Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein. Roemer, T., Madden, K., Chang, J., Snyder, M. Genes Dev. (1996) [Pubmed]
  3. O-Glycosylation of Axl2/Bud10p by Pmt4p is required for its stability, localization, and function in daughter cells. Sanders, S.L., Gentzsch, M., Tanner, W., Herskowitz, I. J. Cell Biol. (1999) [Pubmed]
  4. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme, A., Michelitch, M., Mitchell, E.L., Chant, J. Curr. Biol. (1996) [Pubmed]
  5. Erv14p directs a transmembrane secretory protein into COPII-coated transport vesicles. Powers, J., Barlowe, C. Mol. Biol. Cell (2002) [Pubmed]
  6. The roles of bud-site-selection proteins during haploid invasive growth in yeast. Cullen, P.J., Sprague, G.F. Mol. Biol. Cell (2002) [Pubmed]
  7. Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle. Gao, X.D., Sperber, L.M., Kane, S.A., Tong, Z., Tong, A.H., Boone, C., Bi, E. Mol. Biol. Cell (2007) [Pubmed]
WikiGenes - Universities