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Gene Review: 

MUP1  -  Mup1p

Saccharomyces cerevisiae S288c

Synonyms: High-affinity methionine permease, YGR055W
 
 
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High impact information on MUP1

  • The two methionine permeases encoded by genes MUP1 and MUP3 are only distantly related to this family and thus define a new family of amino acid transporters [1].
  • The study of MUP1 mutants showed that methionine is transported into yeast cells by three different permeases, a high affinity and two low affinity permeases [1].
  • Database comparisons revealed that the yeast genome contains an ORF whose product is highly similar to the MUP1 protein [1].
  • Constitutive overexpression of the genes for glutamine permease ( GNP1) or methionine permease ( MUP1) enhanced the assimilation of glutamine or methionine in the ssy1Delta strain but could not fully suppress the derepression of the NCR-sensitive genes or MET genes [2].
  • MUP1, high affinity methionine permease, is involved in cysteine uptake by Saccharomyces cerevisiae [3].
 

Associations of MUP1 with chemical compounds

References

  1. The study of methionine uptake in Saccharomyces cerevisiae reveals a new family of amino acid permeases. Isnard, A.D., Thomas, D., Surdin-Kerjan, Y. J. Mol. Biol. (1996) [Pubmed]
  2. Genome-wide expression analysis of genes affected by amino acid sensor Ssy1p in Saccharomyces cerevisiae. Kodama, Y., Omura, F., Takahashi, K., Shirahige, K., Ashikari, T. Curr. Genet. (2002) [Pubmed]
  3. MUP1, high affinity methionine permease, is involved in cysteine uptake by Saccharomyces cerevisiae. Kosugi, A., Koizumi, Y., Yanagida, F., Udaka, S. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
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