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Gene Review:

RSC1 - Rsc1p

Saccharomyces cerevisiae S288c

Synonyms: Chromatin structure-remodeling complex subunit RSC1, RSC complex subunit RSC1, Remodel the structure of chromatin complex subunit 1, YGR056W

Bungard, D. et al., Cairns, B.R. et al., Ng, H.H. et al., Yukawa, M. et al., Shim, E.Y. et al.

Cairns, Schlichter, Erdjument-Bromage, Tempst, Kornberg, Winston,

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High impact information on RSC1

Genome-wide location analysis indicates that the yeast nucleosome-remodeling complex RSC has approximately 700 physiological targets and that the Rsc1 and Rsc2 isoforms of the complex behave indistinguishably [1].
Rsc1 and Rsc2 each contain two bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook [2].
The interaction of Rsc1p with Mre11p appears to be vital for survival from genotoxic stress [3].
High-copy-number RSC1 plasmids do not suppress rsc2-Delta/rsc2-Delta sporulation defects, and high-copy-number RSC2 plasmids do not suppress rsc1-Delta/rsc1-Delta sporulation defects [4].
Our data suggest that Smk1 and Rsc1/2 define parallel pathways that converge to provide signaling information and the expression of gene products, respectively, that are required for spore morphogenesis [4].

Biological context of RSC1

Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process [5].
One of the bromodomains, the BAH domain, and the AT hook are each essential for Rsc1 and Rsc2 functions, although they are not required for assembly into RSC complexes [2].

Other interactions of RSC1

Mid-late sporulation-specific genes, which are normally expressed while key steps in spore assembly occur and which include genes that are required for spore wall formation, are not expressed in cells lacking Rsc1 or Rsc2 [4].

References

Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex. Ng, H.H., Robert, F., Young, R.A., Struhl, K. Genes Dev. (2002) [Pubmed]
Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Cairns, B.R., Schlichter, A., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D., Winston, F. Mol. Cell (1999) [Pubmed]
The yeast chromatin remodeler RSC complex facilitates end joining repair of DNA double-strand breaks. Shim, E.Y., Ma, J.L., Oum, J.H., Yanez, Y., Lee, S.E. Mol. Cell. Biol. (2005) [Pubmed]
RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Bungard, D., Reed, M., Winter, E. Eukaryotic Cell (2004) [Pubmed]
Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process. Yukawa, M., Koyama, H., Miyahara, K., Tsuchiya, E. FEMS Yeast Res. (2002) [Pubmed]

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AGOS_ABL005C	Ashbya gossypii ATCC 10895
KLLA0B13211g	Kluyveromyces lactis NRRL Y-1140
RSC2	Saccharomyces cerevisiae S288c

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