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Gene Review

RSC1  -  Rsc1p

Saccharomyces cerevisiae S288c

Synonyms: Chromatin structure-remodeling complex subunit RSC1, RSC complex subunit RSC1, Remodel the structure of chromatin complex subunit 1, YGR056W
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High impact information on RSC1

  • Genome-wide location analysis indicates that the yeast nucleosome-remodeling complex RSC has approximately 700 physiological targets and that the Rsc1 and Rsc2 isoforms of the complex behave indistinguishably [1].
  • Rsc1 and Rsc2 each contain two bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook [2].
  • The interaction of Rsc1p with Mre11p appears to be vital for survival from genotoxic stress [3].
  • High-copy-number RSC1 plasmids do not suppress rsc2-Delta/rsc2-Delta sporulation defects, and high-copy-number RSC2 plasmids do not suppress rsc1-Delta/rsc1-Delta sporulation defects [4].
  • Our data suggest that Smk1 and Rsc1/2 define parallel pathways that converge to provide signaling information and the expression of gene products, respectively, that are required for spore morphogenesis [4].

Biological context of RSC1

  • Functional differences between RSC1 and RSC2, components of a for growth essential chromatin-remodeling complex of Saccharomyces cerevisiae, during the sporulation process [5].
  • One of the bromodomains, the BAH domain, and the AT hook are each essential for Rsc1 and Rsc2 functions, although they are not required for assembly into RSC complexes [2].

Other interactions of RSC1

  • Mid-late sporulation-specific genes, which are normally expressed while key steps in spore assembly occur and which include genes that are required for spore wall formation, are not expressed in cells lacking Rsc1 or Rsc2 [4].


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