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Gene Review

SPS1  -  Sps1p

Saccharomyces cerevisiae S288c

Synonyms: D9719.27, Sporulation-specific protein 1, YDR523C
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Disease relevance of SPS1


High impact information on SPS1


Biological context of SPS1

  • Deletion of SPS1 impinges on the formation of the spore wall, which surrounds each of the haploid nuclei generated by the meiotic divisions [5].
  • SWM1 is expressed at low levels during vegetative growth but its transcription is strongly induced under sporulating conditions, with kinetics similar to those of middle sporulation-specific genes [6].
  • All of the phenotypes observed are similar to those found for the deletion of SPS1 or SMK1, two putative components of a sporulation-specific MAP kinase cascade [6].
  • The 3' end of the transcript encoded by the SPS1 gene was found to map only 185 base pairs from the 5' end of the SPS2 gene [7].
  • A diploid MATa/MAT alpha strain homozygous for a disruption of the SPS1 gene failed to form asci when subjected to sporulation conditions [7].

Anatomical context of SPS1

  • Here, we demonstrate that the new internal membranes that surround the meiotic nuclei appear normal in the absence of Sps1p [5].

Associations of SPS1 with chemical compounds


Co-localisations of SPS1

  • Sps1p colocalized with Chs3p to peripheral and internal punctate structures and prospore membranes [5].

Regulatory relationships of SPS1


Other interactions of SPS1


Analytical, diagnostic and therapeutic context of SPS1

  • We tested two separate libraries built by random ligation of a single type of activator site either for a well-characterized sporulation factor, Ndt80, or for a new sporulation-specific regulatory site that we identified and several neutral spacer elements [14].
  • H4 S1ph may promote chromatin compaction, since deletion of SPS1 increases accessibility to antibody immunoprecipitation; furthermore, either deletion of Sps1 or an H4 S1A substitution results in increased DNA volume in nuclei within spores [15].


  1. Identification and subcellular localization of two solanesyl diphosphate synthases from Arabidopsis thaliana. Jun, L., Saiki, R., Tatsumi, K., Nakagawa, T., Kawamukai, M. Plant Cell Physiol. (2004) [Pubmed]
  2. Mutation of the SPS1-encoded protein kinase of Saccharomyces cerevisiae leads to defects in transcription and morphology during spore formation. Friesen, H., Lunz, R., Doyle, S., Segall, J. Genes Dev. (1994) [Pubmed]
  3. Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80. Chu, S., Herskowitz, I. Mol. Cell (1998) [Pubmed]
  4. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae. Xie, J., Pierce, M., Gailus-Durner, V., Wagner, M., Winter, E., Vershon, A.K. EMBO J. (1999) [Pubmed]
  5. Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis. Iwamoto, M.A., Fairclough, S.R., Rudge, S.A., Engebrecht, J. Eukaryotic Cell (2005) [Pubmed]
  6. SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. Ufano, S., San-Segundo, P., del Rey, F., Vázquez de Aldana, C.R. Mol. Cell. Biol. (1999) [Pubmed]
  7. Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae. Percival-Smith, A., Segall, J. Mol. Cell. Biol. (1986) [Pubmed]
  8. Activity of phosphoforms and truncated versions of Ndt80, a checkpoint-regulated sporulation-specific transcription factor of Saccharomyces cerevisiae. Shubassi, G., Luca, N., Pak, J., Segall, J. Mol. Genet. Genomics (2003) [Pubmed]
  9. Transcriptional regulation of the SMK1 mitogen-activated protein kinase gene during meiotic development in Saccharomyces cerevisiae. Pierce, M., Wagner, M., Xie, J., Gailus-Durner, V., Six, J., Vershon, A.K., Winter, E. Mol. Cell. Biol. (1998) [Pubmed]
  10. Positive control of sporulation-specific genes by the IME1 and IME2 products in Saccharomyces cerevisiae. Mitchell, A.P., Driscoll, S.E., Smith, H.E. Mol. Cell. Biol. (1990) [Pubmed]
  11. NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae. Hepworth, S.R., Friesen, H., Segall, J. Mol. Cell. Biol. (1998) [Pubmed]
  12. CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion. Schaber, M., Lindgren, A., Schindler, K., Bungard, D., Kaldis, P., Winter, E. Mol. Cell. Biol. (2002) [Pubmed]
  13. RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae. Bungard, D., Reed, M., Winter, E. Eukaryotic Cell (2004) [Pubmed]
  14. Gene expression from random libraries of yeast promoters. Ligr, M., Siddharthan, R., Cross, F.R., Siggia, E.D. Genetics (2006) [Pubmed]
  15. Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis. Krishnamoorthy, T., Chen, X., Govin, J., Cheung, W.L., Dorsey, J., Schindler, K., Winter, E., Allis, C.D., Guacci, V., Khochbin, S., Fuller, M.T., Berger, S.L. Genes Dev. (2006) [Pubmed]
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