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Gene Review

BIO2  -  biotin synthase

Saccharomyces cerevisiae S288c

Synonyms: Biotin synthase, mitochondrial, YGR286C
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Disease relevance of BIO2

  • Analysis of the yeast protein encoded by the BIO2 gene reveals that it shares extensive homology with biotin synthases of E. coli and Bacillus sphaericus [1].

High impact information on BIO2

  • Expression of BIO2 was higher in the light relative to dark and was induced 5-fold during biotin-limited conditions [2].
  • Comparisons of the deduced amino acid sequence from BIO2 with bacterial and yeast biotin synthase homologs revealed a high degree of sequence similarity [2].
  • Although BIO2 is physically linked to ZUO1, which encodes the putative left-handed Z-DNA binding protein zuotin, it appears to be regulated independently from it [1].
  • The plasmid pUCBIO2 containing the yeast BIO2 gene completely complements E. coli bioB- and delta bio mutants and enables these mutants to grow on dethiobiotin [1].
  • A series of plasmids were constructed to direct the integration of the BIO2 gene, either high-copy integration with 18S rDNA fragment or low-copy integration with URA3 or HIS3 fragment [3].

Biological context of BIO2


Associations of BIO2 with chemical compounds

  • BIO2 is the first eukaryotic gene reported from the biotin biosynthetic pathway [1].


  1. The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase. Zhang, S., Sanyal, I., Bulboaca, G.H., Rich, A., Flint, D.H. Arch. Biochem. Biophys. (1994) [Pubmed]
  2. Biotin synthase from Arabidopsis thaliana. cDNA isolation and characterization of gene expression. Patton, D.A., Johnson, M., Ward, E.R. Plant Physiol. (1996) [Pubmed]
  3. Recombinant Candida utilis for the production of biotin. Hong, Y.R., Chen, Y.L., Farh, L., Yang, W.J., Liao, C.H., Shiuan, D. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
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