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Gene Review

ZUO1  -  zuotin

Saccharomyces cerevisiae S288c

Synonyms: DnaJ-related protein ZUO1, Heat shock protein 40 homolog ZUO1, J protein ZUO1, Ribosome-associated complex subunit ZUO1, YGR285C, ...
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Disease relevance of ZUO1

  • The hexapeptide motif KYHPDK was found in zuotin as well as in several yeast proteins, DnaJ of E.coli, csp29 and csp32 proteins of Drosophila and the small t and large T antigens of the polyoma virus [1].

Psychiatry related information on ZUO1

  • MIDA1 associates with the HLH region of Id with the conserved region adjacent to eukaryotic DnaJ conserved motif within the Zuotin homology region, although it does not have any canonical HLH motif [2].

High impact information on ZUO1

  • Analysis of zuo1 deletion and truncation mutants revealed a positive correlation between the ribosome association of Zuo1 and its ability to bind RNA [3].
  • Here we report that the phenotypes of an S.cerevisiae strain lacking the DnaJ-related protein Zuotin (Zuo1) are very similar to those of a strain lacking Ssb, including sensitivities to low temperatures, certain protein synthesis inhibitors and high osmolarity [3].
  • Zuo1, which has been shown previously to be a nucleic acid-binding protein, is also a ribosome-associated protein localized predominantly in the cytosol [3].
  • Poly(dG-Br5dC) in the Z-form competed well for the binding of a zuotin containing fraction, but salmon sperm DNA, poly(dG-dC) and poly(dA-dT) were not effective [1].
  • However, a 50- to 100-fold reduction of Ssz1 and Zuo1 levels does not have a substantial effect on cell growth [4].

Chemical compound and disease context of ZUO1

  • This protein is named MIDA1 (Mouse Id Associate 1), and its predicted amino acid sequence consists of Zuotin (a putative Z-DNA binding protein in yeast) homology region and tryptophan-mediated repeats similar to c-Myb oncoprotein [2].

Biological context of ZUO1


Anatomical context of ZUO1

  • In addition, Pdr13p co-sedimented with translating ribosomes and this association was independent of the presence of Zuo1p [7].

Other interactions of ZUO1


Analytical, diagnostic and therapeutic context of ZUO1

  • In a gel retardation assay poly(dG-m5dC) in the Z-form strongly diminishes the binding of tRNA to zuotin [10].
  • Analysis of published DNA microarray experiments reveals conditions under which Ssb1, Ssb2, Ssz1, and Zuo1 transcript levels are regulated independently of those of genes encoding ribosomal proteins [11].


  1. Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae. Zhang, S., Lockshin, C., Herbert, A., Winter, E., Rich, A. EMBO J. (1992) [Pubmed]
  2. MIDA1, a protein associated with Id, regulates cell growth. Shoji, W., Inoue, T., Yamamoto, T., Obinata, M. J. Biol. Chem. (1995) [Pubmed]
  3. Zuotin, a ribosome-associated DnaJ molecular chaperone. Yan, W., Schilke, B., Pfund, C., Walter, W., Kim, S., Craig, E.A. EMBO J. (1998) [Pubmed]
  4. The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain. Hundley, H., Eisenman, H., Walter, W., Evans, T., Hotokezaka, Y., Wiedmann, M., Craig, E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase. Zhang, S., Sanyal, I., Bulboaca, G.H., Rich, A., Flint, D.H. Arch. Biochem. Biophys. (1994) [Pubmed]
  6. Cloning and chromosomal localization of a mouse cDNA with homology to the Saccharomyces cerevisiae gene zuotin. Hughes, R., Chan, F.Y., White, R.A., Zon, L.I. Genomics (1995) [Pubmed]
  7. Yeast Pdr13p and Zuo1p molecular chaperones are new functional Hsp70 and Hsp40 partners. Michimoto, T., Aoki, T., Toh-e, A., Kikuchi, Y. Gene (2000) [Pubmed]
  8. Sequence analysis of a near-subtelomeric 35.4 kb DNA segment on the right arm of chromosome VII from Saccharomyces cerevisiae carrying the MAL1 locus reveals 15 complete open reading frames, including ZUO1, BGL2 and BIO2 genes and an ABC transporter gene. Volckaert, G., Voet, M., Robben, J. Yeast (1997) [Pubmed]
  9. Activation of pleiotropic drug resistance by the J-protein and Hsp70-related proteins, Zuo1 and Ssz1. Eisenman, H.C., Craig, E.A. Mol. Microbiol. (2004) [Pubmed]
  10. Transfer RNA binding protein in the nucleus of Saccharomyces cerevisiae. Wilhelm, M.L., Reinbolt, J., Gangloff, J., Dirheimer, G., Wilhelm, F.X. FEBS Lett. (1994) [Pubmed]
  11. Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting. Muldoon-Jacobs, K.L., Dinman, J.D. Eukaryotic Cell (2006) [Pubmed]
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