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Gene Review

GPI14  -  Gpi14p

Saccharomyces cerevisiae S288c

Synonyms: GPI mannosyltransferase 1, GPI mannosyltransferase I, GPI-MT-I, Glycosylphosphatidylinositol-anchor biosynthesis protein 14, J1444, ...
 
 
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High impact information on GPI14

  • Downregulation of GPI14 expression/reduced protein function due to an amino terminal deletion resulted in increased transcription and production of an endogenous and a heterologous secreted protein expressed from HSP150 and ADH1 promoter, respectively [1].
  • We report here identification and characterization of a mutation in the GPI14 gene, the yeast homologue of the mammalian PIG-M that functions in the synthesis of the GPI moiety anchoring proteins to the plasma membrane [1].
  • Characterization of GPI14/YJR013w mutation that induces the cell wall integrity signalling pathway and results in increased protein production in Saccharomyces cerevisiae [1].
  • A cell wall defect in the gpi14 mutant cells was suggested by cell aggregation phenotype, increased sensitivity to Calcofluor white, an increased release of Gas1p and total protein into the culture medium [1].

References

 
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