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Gene Review

GEA1  -  Gea1p

Saccharomyces cerevisiae S288c

Synonyms: ARF guanine-nucleotide exchange factor 1, J1580, YJR031C
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High impact information on GEA1

  • Gea1 contains a domain that is similar to a domain of Sec7, a protein necessary for intra-Golgi transport [1].
  • We show that the activity of the complex is sensitive to brefeldin A and that Gea1 function is necessary for ER-Golgi transport in vivo [1].
  • We provide multiple genetic and biochemical evidence for an interaction between Ysl12p and the Arf-like protein Arl1p, consistent with a potential function as an Arf guanine nucleotide exchange factor (GEF) [2].
  • This interaction involves a domain of Gea1p and Gea2p that is conserved in the eukaryotic orthologues of the Gea proteins [3].
  • Conditional mutants defective in both GEA1 and GEA2 accumulate endoplasmic reticulum and Golgi membranes under restrictive conditions [4].

Biological context of GEA1

  • The GEA1 and GEA2 genes, which code for paralog guanosine exchange factors for Arf proteins, were identified as multicopy suppressors of the mutant phenotype [5].

Anatomical context of GEA1


Other interactions of GEA1

  • Several proteins that belong to the Sec7-domain family, including the yeast Gea1p, have recently been shown to stimulate nucleotide exchange by Arf GTPases [7].


  1. Nucleotide exchange on ARF mediated by yeast Gea1 protein. Peyroche, A., Paris, S., Jackson, C.L. Nature (1996) [Pubmed]
  2. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Jochum, A., Jackson, D., Schwarz, H., Pipkorn, R., Singer-Krüger, B. Mol. Cell. Biol. (2002) [Pubmed]
  3. A novel Golgi membrane protein is a partner of the ARF exchange factors Gea1p and Gea2p. Chantalat, S., Courbeyrette, R., Senic-Matuglia, F., Jackson, C.L., Goud, B., Peyroche, A. Mol. Biol. Cell (2003) [Pubmed]
  4. The ADP ribosylation factor-nucleotide exchange factors Gea1p and Gea2p have overlapping, but not redundant functions in retrograde transport from the Golgi to the endoplasmic reticulum. Spang, A., Herrmann, J.M., Hamamoto, S., Schekman, R. Mol. Biol. Cell (2001) [Pubmed]
  5. A role for GEA1 and GEA2 in the organization of the actin cytoskeleton in Saccharomyces cerevisiae. Zakrzewska, E., Perron, M., Laroche, A., Pallotta, D. Genetics (2003) [Pubmed]
  6. The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast. Peyroche, A., Courbeyrette, R., Rambourg, A., Jackson, C.L. J. Cell. Sci. (2001) [Pubmed]
  7. Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers. Jones, S., Jedd, G., Kahn, R.A., Franzusoff, A., Bartolini, F., Segev, N. Genetics (1999) [Pubmed]
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