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Gene Review:

RAV1 - Rav1p

Saccharomyces cerevisiae S288c

Synonyms: J1590, Regulator of V-ATPase in vacuolar membrane protein 1, SOI3, Suppression of the onset of impotence protein 3, YJR033C

Sipos, G. et al., Brace, E.J. et al., Sohn, K.H. et al.

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High impact information on RAV1

SOI3 was identified by a mutation, soi3-1, that suppressed a mutant trans-Golgi network (TGN) localization signal in the Kex2p cytosolic tail [1].
The soi3 null mutation markedly reduced the rate of Kex2p transport from the TGN to the PVC but had no effect on vacuolar protein sorting or cycling of Vps10p [1].
Here, we show that Soi3/Rav1p is required for transport between the early endosome and the late endosome/prevacuolar compartment (PVC) [1].
Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins [1].
Expression and functional roles of the pepper pathogen-induced transcription factor RAV1 in bacterial disease resistance, and drought and salt stress tolerance [2].

Anatomical context of RAV1

However, in the skp1(Asn108Tyr) mutant strain, the membrane-associated pool of Rav1-green fluorescent protein was increased, suggesting that Skp1p is important for the release of Rav1p from endosomal membranes where it functions in V-ATPase assembly [3].

References

Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins. Sipos, G., Brickner, J.H., Brace, E.J., Chen, L., Rambourg, A., Kepes, F., Fuller, R.S. Mol. Biol. Cell (2004) [Pubmed]
Expression and functional roles of the pepper pathogen-induced transcription factor RAV1 in bacterial disease resistance, and drought and salt stress tolerance. Sohn, K.H., Lee, S.C., Jung, H.W., Hong, J.K., Hwang, B.K. Plant Mol. Biol. (2006) [Pubmed]
Skp1p regulates soi3p/rav1p association with endosomal membranes but is not required for vacuolar ATPase assembly. Brace, E.J., Parkinson, L.P., Fuller, R.S. Eukaryotic Cell (2006) [Pubmed]

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AGOS_AEL063W	Ashbya gossypii ATCC 10895
KLLA0E22683g	Kluyveromyces lactis NRRL Y-1140
MGG_11430	Magnaporthe oryzae 70-15
NCU01658	Neurospora crassa OR74A
rav1	Schizosaccharomyces pombe 972h-

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