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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RSF2  -  Rsf2p

Saccharomyces cerevisiae S288c

Synonyms: J2052, Respiration factor 2, YJR127C, ZMS1, Zinc finger protein ZMS1
 
 
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High impact information on RSF2

  • Another multicopy suppressor identified in our screen, the ZMS1 gene encoding a putative transcription factor, regulates the level of ALD6 expression [1].
  • The YJR127C/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae [2].
  • A putative yeast mitochondrial upstream activating sequence (UAS) was used in a one-hybrid screening procedure that identified the YJR127C ORF on chromosome X. This gene was previously designated ZMS1 and is listed as a transcription factor on the SGD website [2].
 

Associations of RSF2 with chemical compounds

  • Thus, the product of YJR127C/ZMS1 is involved in transcriptional control for genes in both cellular genetic compartments, many of which specify products required for glycerol-based growth, respiration, and other functions [2].
 

Analytical, diagnostic and therapeutic context of RSF2

  • Real time RT-PCR assays showed that expression of YJR127C/ZMS1 was glucose-repressible, and a deletion mutant for the gene showed a growth defect on glycerol-based but not on glucose- or ethanol-based medium [2].

References

  1. The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose-6-phosphate dehydrogenase activity. Grabowska, D., Chelstowska, A. J. Biol. Chem. (2003) [Pubmed]
  2. The YJR127C/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae. Lu, L., Roberts, G.G., Oszust, C., Hudson, A.P. Curr. Genet. (2005) [Pubmed]
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