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Gene Review

TPK3  -  cAMP-dependent protein kinase catalytic...

Saccharomyces cerevisiae S288c

Synonyms: PKA 3, PKA3, YKL166C, YKL630, cAMP-dependent protein kinase type 3
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High impact information on TPK3

  • Although they are redundant for viability, the three A kinases are not redundant for pseudohyphal growth [Robertson, L. S. & Fink, G. R. (1998) Proc. Natl. Acad. Sci. USA 95, 13783-13787; Pan, X. & Heitman, J. (1999) Mol. Cell. Biol. 19, 4874-4887]; Tpk2, but not Tpk1 or Tpk3, is required for pseudohyphal growth [1].
  • We demonstrate that they have dramatically different roles in pseudohyphal development: Tpk2 is essential, whereas Tpk3 inhibits [2].
  • The effect of cAMP elevation in inducing actin-mediated apoptosis functions primarily through the Tpk3p subunit of protein kinase A. This pathway represents the first defined link between environmental sensing, actin remodeling, and apoptosis in Saccharomyces cerevisiae [3].
  • Nucleotide sequencing revealed that MRP49 is tightly linked to TPK3 and encodes a 16-kDa, basic protein with no significant relatedness to any other known protein [4].
  • Moreover, BCY1 overexpression not only increased Tpk3 catalytic activity but also increased the amount of TPK3 mRNA detected in Northern blots [5].

Biological context of TPK3


Associations of TPK3 with chemical compounds

  • Furthermore, it is shown that the three PKAs in yeast, Tpk1, Tpk2 and Tpk3, have redundant functions in regulating APC/C in response to glucose medium [6].

Enzymatic interactions of TPK3

  • The strain containing TPK3 as the only intact TPK gene showed nearly undetectable phosphorylating activity and no TPK3 mRNA could be detected, although the cells grow normally [5].

Other interactions of TPK3

  • In this study, we show that the repression activity of Rgt1 is regulated by Snf1 and Tpk3 protein kinases [7].


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