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Gene Review

TEF4  -  Tef4p

Saccharomyces cerevisiae S288c

Synonyms: EF-1-gamma 2, EFC1, Elongation factor 1-gamma 2, Eukaryotic elongation factor 1Bgamma 2, Translation elongation factor 1B gamma 2, ...
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High impact information on TEF4

  • We identified SAL6, TEF4, and YDL219w, all of which likely affect nonsense suppression via alteration of the protein synthesis machinery [1].
  • The cold-sensitive phenotype of drs2 is suppressed by extra copies of the TEF3 gene, which encodes a yeast homolog of eukaryotic translation elongation factor EF-1 gamma [2].
  • However, the second form of eEF1Bgamma encoded by the TEF4 gene contains serine 11, which may act catalytically [3].
  • Ten cDNA clones were identified as transcriptional enhancer factor-4 (TEF-4) [4].
  • When COS-7 cells were transfected with TEF-4, CCTalpha promoter-luciferase reporter activity and CCTalpha mRNA levels increased [4].

Biological context of TEF4

  • These results provide the first evidence that TEF-4 is an important regulator of CCTalpha gene expression [4].

Other interactions of TEF4

  • Unlike TEF3, extra copies of TEF4 do not suppress the cold-sensitive 40S ribosomal subunit deficiency of a drs2 strain [5].

Analytical, diagnostic and therapeutic context of TEF4

  • Gel-shift analysis using radiolabeled Eb fragment as a probe showed that cell extracts from yeast expressing hemagglutinin-tagged TEF-4 caused a marked band retardation that could be prevented with an anti-hemagglutinin antibody [4].


  1. Competition between a sterol biosynthetic enzyme and tRNA modification in addition to changes in the protein synthesis machinery causes altered nonsense suppression. Benko, A.L., Vaduva, G., Martin, N.C., Hopper, A.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. DRS1 to DRS7, novel genes required for ribosome assembly and function in Saccharomyces cerevisiae. Ripmaster, T.L., Vaughn, G.P., Woolford, J.L. Mol. Cell. Biol. (1993) [Pubmed]
  3. The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. Jeppesen, M.G., Ortiz, P., Shepard, W., Kinzy, T.G., Nyborg, J., Andersen, G.R. J. Biol. Chem. (2003) [Pubmed]
  4. Identification of transcriptional enhancer factor-4 as a transcriptional modulator of CTP:phosphocholine cytidylyltransferase alpha. Sugimoto, H., Bakovic, M., Yamashita, S., Vance, D.E. J. Biol. Chem. (2001) [Pubmed]
  5. Multiple genes encode the translation elongation factor EF-1 gamma in Saccharomyces cerevisiae. Kinzy, T.G., Ripmaster, T.L., Woolford, J.L. Nucleic Acids Res. (1994) [Pubmed]
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