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Gene Review

CAM1  -  Cam1p

Saccharomyces cerevisiae S288c

Synonyms: CPBP, Calcium and membrane-binding protein 1, Calcium phospholipid-binding protein, EF-1-gamma 1, Elongation factor 1-gamma 1, ...
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High impact information on CAM1

  • In a mutant yeast strain lacking the CPBP-encoding gene, the ability to overexpress msrA mRNA and MsrA protein was impaired and MsrA catalytic activity was greatly reduced, suggesting that CPBP may enhance msrA gene expression [1].
  • By measuring CPBP cooperative binding to the msrA promoter, we have mapped the CPBP binding site to a 39-bp sequence at the 3' end of the promoter [1].
  • This gene, which is unique in the S. pombe genome and is named cam1, encodes 149 amino acids excluding the first methionine and is transcribed into mRNA of 1.2-kb length [2].
  • Spores bearing disrupted cam1 halt growth soon after germination and rarely carry out the first cell division, indicating that calmodulin does not exist in excess in those cells [2].
  • However, the second form of eEF1Bgamma encoded by the TEF4 gene contains serine 11, which may act catalytically [3].

Biological context of CAM1


Anatomical context of CAM1

  • Immunocytochemical studies showed that D3R and eEF1Bgamma form clusters on the plasma membrane and their co-localization was evident in these clusters [7].

Associations of CAM1 with chemical compounds


  1. A homologue of elongation factor 1 gamma regulates methionine sulfoxide reductase A gene expression in Saccharomyces cerevisiae. Hanbauer, I., Boja, E.S., Moskovitz, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Analysis and in vivo disruption of the gene coding for calmodulin in Schizosaccharomyces pombe. Takeda, T., Yamamoto, M. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  3. The crystal structure of the glutathione S-transferase-like domain of elongation factor 1Bgamma from Saccharomyces cerevisiae. Jeppesen, M.G., Ortiz, P., Shepard, W., Kinzy, T.G., Nyborg, J., Andersen, G.R. J. Biol. Chem. (2003) [Pubmed]
  4. Cloning and genetic characterization of a calcium- and phospholipid-binding protein from Saccharomyces cerevisiae that is homologous to translation elongation factor-1 gamma. Kambouris, N.G., Burke, D.J., Creutz, C.E. Yeast (1993) [Pubmed]
  5. The yeast cytosolic thioredoxins are involved in the regulation of methionine sulfoxide reductase A. Hanbauer, I., Moskovitz, J. Free Radic. Biol. Med. (2006) [Pubmed]
  6. Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. Matsumoto, K., Uno, I., Toh-E, A., Ishikawa, T., Oshima, Y. J. Bacteriol. (1982) [Pubmed]
  7. Direct and biochemical interaction between dopamine D3 receptor and elongation factor-1Bbetagamma. Cho, D.I., Oak, M.H., Yang, H.J., Choi, H.K., Janssen, G.M., Kim, K.M. Life Sci. (2003) [Pubmed]
  8. Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation. Bec, G., Kerjan, P., Waller, J.P. J. Biol. Chem. (1994) [Pubmed]
  9. The Translation Elongation Factor eEF1B plays a role in the oxidative stress response pathway. Olarewaju, O., Ortiz, P.A., Chowdhury, W.Q., Chatterjee, I., Kinzy, T.G. RNA biology (2004) [Pubmed]
  10. The 110kDa glutathione transferase of Yarrowia lipolytica is encoded by a homologue of the TEF3 gene from Saccharomyces cerevisiae: cloning, expression, and homology modeling of the recombinant protein. McGoldrick, S., McCarthy, T.V., Sheehan, D. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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