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Gene Review: 

SWD2  -  Swd2p

Saccharomyces cerevisiae S288c

Synonyms: COMPASS component SWD2, CPS35, Complex proteins associated with SET1 protein SWD2, SAF37, Set1C component SWD2, ...
 
 
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High impact information on SWD2

  • One Set1C member, Swd2/Cpf10 is also present in cleavage polyadenylation factor (CPF) [1].
  • Some swd2 mutations also significantly decrease global H3-K4 methylation and cause other phenotypes associated with loss of this chromatin modification, such as loss of telomere silencing, hydroxyurea sensitivity, and alterations in repression of INO1 transcription [2].
  • Overexpression of Ref2, a protein previously implicated in snoRNA 3' end formation and Swd2 recruitment to CPF, can rescue the growth and termination defects, indicating a functional interaction between the two proteins [2].
  • Swd2, an essential WD repeat protein in Saccharomyces cerevisiae, is a component of two very different complexes: the cleavage and polyadenylation factor CPF and the Set1 methylase, which modifies lysine 4 of histone H3 (H3-K4) [2].
  • The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3 [2].

References

  1. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. Roguev, A., Schaft, D., Shevchenko, A., Pijnappel, W.W., Wilm, M., Aasland, R., Stewart, A.F. EMBO J. (2001) [Pubmed]
  2. The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Cheng, H., He, X., Moore, C. Mol. Cell. Biol. (2004) [Pubmed]
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