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Gene Review:

DAD2 - Dad2p

Saccharomyces cerevisiae S288c

Synonyms: DASH complex subunit DAD2, DUO1 and DAM1-interacting protein 2, HSK1, Helper of ASK1 protein 1, Outer kinetochore protein DAD2, ...

Ogino, K. et al., Ogino, K. et al., Matsumoto, S. et al.

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High impact information on DAD2

Here, we report that Hsk1, the Cdc7-related kinase in Schizosaccharomyces pombe, plays a crucial role during meiosis [1].
These results indicate unique and essential roles of Hsk1 kinase in the initiation of meiotic recombination and meiosis [1].
The protein kinase Hsk1 is essential for DNA replication in Schizosaccharomyces pombe [2].
Dfp1/Him1 protein of fission yeast, Schizosaccharomyces pombe, encodes the regulatory subunit for Hsk1 kinase, a homologue of budding yeast Cdc7 kinase essential for initiation and progression of the S phase of the cell cycle [3].

References

Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast. Ogino, K., Hirota, K., Matsumoto, S., Takeda, T., Ohta, K., Arai, K., Masai, H. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
Hsk1-Dfp1/Him1, the Cdc7-Dbf4 kinase in Schizosaccharomyces pombe, associates with Swi1, a component of the replication fork protection complex. Matsumoto, S., Ogino, K., Noguchi, E., Russell, P., Masai, H. J. Biol. Chem. (2005) [Pubmed]
Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. Ogino, K., Takeda, T., Matsui, E., Iiyama, H., Taniyama, C., Arai , K., Masai, H. J. Biol. Chem. (2001) [Pubmed]

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AGOS_ADR217C	Ashbya gossypii ATCC 10895
KLLA0A07887g	Kluyveromyces lactis NRRL Y-1140

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