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Gene Review

MDH2  -  malate dehydrogenase MDH2

Saccharomyces cerevisiae S288c

Synonyms: Malate dehydrogenase, cytoplasmic, YOL126C
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High impact information on MDH2

  • The deduced amino acid sequence was closely related to those of MDH1 (50% residue identity) and of MDH2 (43% residue identity) [1].
  • Glucose-induced degradation of the MDH2 isozyme of malate dehydrogenase in yeast [2].
  • An extended lag in attaining wild type rates of growth on glucose measured for strains expressing the truncated MDH2 enzyme represents the first evidence of a selective advantage for the phenomenon of glucose-induced proteolysis in yeast [2].
  • A truncated form of MDH2 lacking amino acid residues 1-12 was constructed by mutagenesis of the MDH2 gene and expressed in a haploid yeast strain containing a deletion disruption of the corresponding chromosomal gene [2].
  • This TCA cycle function observed for the cytosolic form of MDH1 is unique to that isozyme since overexpression of MDH2 and of a cytosolic form of MDH3 in a deltaMDH1 strain failed to restore growth [3].

Biological context of MDH2


Associations of MDH2 with chemical compounds

  • However, the transcriptional level of the MDH2 gene in strain M20 for days 4 and 8 of malate formation during sake brewing was higher than that in strain K-701 [5].
  • Shifting a yeast culture growing with acetate to medium containing glucose as a carbon source resulted in a 25-fold increase in turnover of MDH2 [2].

Enzymatic interactions of MDH2


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