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Gene Review

AUS1  -  ATP-binding cassette sterol transporter AUS1

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent permease AUS1, YOR011W
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High impact information on AUS1

  • Surprisingly, while expression of Aus1p and Pdr11p significantly increases sterol movement from PM to ER, it does not alter intracellular sterol distribution [1].
  • However, constitutive co-expression of AUS1 and DAN1 in a wild-type background resulted in sterol influx in aerobiosis [2].

Anatomical context of AUS1

  • Among these genes, the role of the putative ABC transporter (ATP-binding-cassette transporter) Aus1, and of the cell-wall mannoprotein Dan1, was characterized better [2].
  • Here we demonstrate that two inducible ATP-binding cassette (ABC) transporters (Aus1p and Pdr11p) mediate nonvesicular movement of PM sterol to the endoplasmic reticulum (ER) in Saccharomyces cerevisiae [1].

Associations of AUS1 with chemical compounds


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