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Gene Review:

AUS1 - ATP-binding cassette sterol transporter AUS1

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent permease AUS1, YOR011W

Li, Y. et al., Alimardani, P. et al., Wilcox, L.J. et al.

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High impact information on AUS1

Surprisingly, while expression of Aus1p and Pdr11p significantly increases sterol movement from PM to ER, it does not alter intracellular sterol distribution [1].
However, constitutive co-expression of AUS1 and DAN1 in a wild-type background resulted in sterol influx in aerobiosis [2].

Anatomical context of AUS1

Among these genes, the role of the putative ABC transporter (ATP-binding-cassette transporter) Aus1, and of the cell-wall mannoprotein Dan1, was characterized better [2].
Here we demonstrate that two inducible ATP-binding cassette (ABC) transporters (Aus1p and Pdr11p) mediate nonvesicular movement of PM sterol to the endoplasmic reticulum (ER) in Saccharomyces cerevisiae [1].

Associations of AUS1 with chemical compounds

We hypothesized that the physiological role of Aus1p and Pdr11p is to mediate sterol uptake when sterol biosynthesis is compromised [3].

References

ATP-binding cassette (ABC) transporters mediate nonvesicular, raft-modulated sterol movement from the plasma membrane to the endoplasmic reticulum. Li, Y., Prinz, W.A. J. Biol. Chem. (2004) [Pubmed]
SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Alimardani, P., Régnacq, M., Moreau-Vauzelle, C., Ferreira, T., Rossignol, T., Blondin, B., Bergès, T. Biochem. J. (2004) [Pubmed]
Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. Wilcox, L.J., Balderes, D.A., Wharton, B., Tinkelenberg, A.H., Rao, G., Sturley, S.L. J. Biol. Chem. (2002) [Pubmed]

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AGOS_AFR326W	Ashbya gossypii ATCC 10895
PDR11	Saccharomyces cerevisiae S288c

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