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Gene Review

DAN1  -  Dan1p

Saccharomyces cerevisiae S288c

Synonyms: CCW13, Cell wall protein DAN1, Covalently-linked cell wall protein 13, Delayed anaerobic protein 1, J2217, ...
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High impact information on DAN1

  • Deletion of the ATP-binding cassette transporters YOR011w (AUS1) or PDR11, or a putative cell wall protein encoded by DAN1, significantly reduced sterol influx [1].
  • Within the promoter sequence of one of these genes, DAN1, we identified the region responsive to SUT1 and showed that it has a strong repressive activity when cloned in the vicinity of distinct promoters [2].
  • Indeed, ectopic expression of MOX4 in aerobic cells resulted in partially constitutive expression of DAN1 [3].
  • Expression of DAN1 was regulated in parallel with the hypoxic gene ANB1, showing identical kinetics of induction and dose response to heme [4].
  • Moreover, the engineered promoters showed a markedly higher maximal expression than the unmutated DAN1 promoter, under both fastidious anaerobiosis and microaerobisois [5].

Biological context of DAN1


Other interactions of DAN1

  • AR1 is found in all of the DAN/TIR promoters; AR2 is found in DAN1, DAN2 and DAN3 [8].


  1. Transcriptional profiling identifies two members of the ATP-binding cassette transporter superfamily required for sterol uptake in yeast. Wilcox, L.J., Balderes, D.A., Wharton, B., Tinkelenberg, A.H., Rao, G., Sturley, S.L. J. Biol. Chem. (2002) [Pubmed]
  2. SUT1p interaction with Cyc8p(Ssn6p) relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces cerevisiae. Régnacq, M., Alimardani, P., El Moudni, B., Bergès, T. Mol. Microbiol. (2001) [Pubmed]
  3. Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae. Abramova, N.E., Cohen, B.D., Sertil, O., Kapoor, R., Davies, K.J., Lowry, C.V. Genetics (2001) [Pubmed]
  4. The DAN1 gene of S. cerevisiae is regulated in parallel with the hypoxic genes, but by a different mechanism. Sertil, O., Cohen, B.D., Davies, K.J., Lowry, C.V. Gene (1997) [Pubmed]
  5. Engineering promoter regulation. Nevoigt, E., Fischer, C., Mucha, O., Matth??us, F., Stahl, U., Stephanopoulos, G. Biotechnol. Bioeng. (2007) [Pubmed]
  6. SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Alimardani, P., Régnacq, M., Moreau-Vauzelle, C., Ferreira, T., Rossignol, T., Blondin, B., Bergès, T. Biochem. J. (2004) [Pubmed]
  7. Transcriptional regulation of YML083c under aerobic and anaerobic conditions. Ter Linde, J.J., Régnacq, M., Steensma, H.Y. Yeast (2003) [Pubmed]
  8. Induction and repression of DAN1 and the family of anaerobic mannoprotein genes in Saccharomyces cerevisiae occurs through a complex array of regulatory sites. Cohen, B.D., Sertil, O., Abramova, N.E., Davies, K.J., Lowry, C.V. Nucleic Acids Res. (2001) [Pubmed]
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