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Gene Review:

IAH1 - Iah1p

Saccharomyces cerevisiae S288c

Synonyms: EST2, Isoamyl acetate-hydrolyzing esterase, O3287, YOR126C, YOR3287C

Lilly, M. et al., Fukuda, K. et al., Fukuda, K. et al.

Fukuda, Kiyokawa, Yanagiuchi, Wakai, Kitamoto, Inoue, Kimura,

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Disease relevance of IAH1

We constructed the IAH1 gene expression system in Escherichia coli, and purified the IAH1 gene product (Iah1p) [1].

High impact information on IAH1

Fermentation profiles as well as components of the resulting sake were largely alike; however, the amount of isoamyl acetate in the sake increased with an increasing ratio of AATFase/Iah1p esterase activity [2].
The overexpression of IAH1 resulted in a significant decrease in ethyl acetate, isoamyl acetate, hexyl acetate and 2-phenylethyl acetate [3].

Associations of IAH1 with chemical compounds

The IAH1 gene of Saccharomyces cerevisiae encodes an esterase that preferentially acts on isoamyl acetate; however, the enzyme has not yet been completely purified from the yeast S. cerevisiae [1].

Analytical, diagnostic and therapeutic context of IAH1

Judging from the molecular weight estimation by gel filtration of purified Iah1p, the enzyme was thought to be a homodimer [1].

References

Purification and characterization of isoamyl acetate-hydrolyzing esterase encoded by the IAH1 gene of Saccharomyces cerevisiae from a recombinant Escherichia coli. Fukuda, K., Kiyokawa, Y., Yanagiuchi, T., Wakai, Y., Kitamoto, K., Inoue, Y., Kimura, A. Appl. Microbiol. Biotechnol. (2000) [Pubmed]
Balance of activities of alcohol acetyltransferase and esterase in Saccharomyces cerevisiae is important for production of isoamyl acetate. Fukuda, K., Yamamoto, N., Kiyokawa, Y., Yanagiuchi, T., Wakai, Y., Kitamoto, K., Inoue, Y., Kimura, A. Appl. Environ. Microbiol. (1998) [Pubmed]
The effect of increased yeast alcohol acetyltransferase and esterase activity on the flavour profiles of wine and distillates. Lilly, M., Bauer, F.F., Lambrechts, M.G., Swiegers, J.H., Cozzolino, D., Pretorius, I.S. Yeast (2006) [Pubmed]

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AT2G38180	Arabidopsis thaliana
AGOS_ACR201C	Ashbya gossypii ATCC 10895
KLLA0E02509g	Kluyveromyces lactis NRRL Y-1140
iah1	Schizosaccharomyces pombe 972h-

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