The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

FRT1  -  Frt1p

Saccharomyces cerevisiae S288c

Synonyms: Functionally related to TCP1 protein 1, HPH1, High pH protein 1, O6159, Protein HPH1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FRT1

  • FRT1 is highly similar to recently identified fructose transporters of yeasts, but much less to other fungal hexose transporters characterized so far [1].
  • Deletion of the FRT1 gene in a K. lactis strain already deleted for its RAG1 and HGT1 hexose transporter genes completely prevented uptake of and growth with fructose but not with glucose [2].
  • Transcription of the FRT1 gene, which was undetectable when cells were grown in ethanol, was induced by various sugars [2].
  • Determination of substrate specificities and kinetic parameters revealed Frt1 as a fructose transporter with a K(m) of 0.16+/-0.02 mM [2].
  • This motif is related to calcineurin docking sites in other substrates, such as NFAT and Crz1p, and is required for regulation of Hph1p by calcineurin [3].

Anatomical context of FRT1

  • Hph1p and Hph2p serve redundant roles in promoting growth under conditions of high salinity, alkaline pH, and cell wall stress [3].
  • Calcineurin modifies the distribution of Hph1p within the endoplasmic reticulum and is required for full Hph1p activity in vivo [3].

Associations of FRT1 with chemical compounds

  • By using a hexose uptake deficient yeast strain for expression, FRT1 was found to be a high affinity proton coupled symporter specific for fructose but not for glucose [1].


WikiGenes - Universities