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Gene Review

AGE2  -  Age2p

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor GTPase-activating protein effector protein 2, ARF GAP effector protein 2, YIL044C
 
 
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High impact information on AGE2

  • Our results demonstrate that the Gcs1 + Age2 ArfGAP pair provides overlapping function for transport from the TGN, and also indicate that multiple activities at the TGN can be maintained with the aid of a single ArfGAP [1].
  • The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network [1].
  • In support, biochemical data indicate that Gcs1p and Age2p ARFGAP activities are both modulated by lipids implicated in regulation of Sec14p pathway function [2].
 

Anatomical context of AGE2

References

  1. The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. Poon, P.P., Nothwehr, S.F., Singer, R.A., Johnston, G.C. J. Cell Biol. (2001) [Pubmed]
  2. Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Yanagisawa, L.L., Marchena, J., Xie, Z., Li, X., Poon, P.P., Singer, R.A., Johnston, G.C., Randazzo, P.A., Bankaitis, V.A. Mol. Biol. Cell (2002) [Pubmed]
  3. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Wong, T.A., Fairn, G.D., Poon, P.P., Shmulevitz, M., McMaster, C.R., Singer, R.A., Johnston, G.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
 
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