The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

AGE2  -  Age2p

Saccharomyces cerevisiae S288c

Synonyms: ADP-ribosylation factor GTPase-activating protein effector protein 2, ARF GAP effector protein 2, YIL044C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on AGE2

  • Our results demonstrate that the Gcs1 + Age2 ArfGAP pair provides overlapping function for transport from the TGN, and also indicate that multiple activities at the TGN can be maintained with the aid of a single ArfGAP [1].
  • The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network [1].
  • In support, biochemical data indicate that Gcs1p and Age2p ARFGAP activities are both modulated by lipids implicated in regulation of Sec14p pathway function [2].

Anatomical context of AGE2


  1. The Gcs1 and Age2 ArfGAP proteins provide overlapping essential function for transport from the yeast trans-Golgi network. Poon, P.P., Nothwehr, S.F., Singer, R.A., Johnston, G.C. J. Cell Biol. (2001) [Pubmed]
  2. Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast. Yanagisawa, L.L., Marchena, J., Xie, Z., Li, X., Poon, P.P., Singer, R.A., Johnston, G.C., Randazzo, P.A., Bankaitis, V.A. Mol. Biol. Cell (2002) [Pubmed]
  3. Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi. Wong, T.A., Fairn, G.D., Poon, P.P., Shmulevitz, M., McMaster, C.R., Singer, R.A., Johnston, G.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
WikiGenes - Universities