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Gene Review

MDM1  -  Mdm1p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial distribution and morphology protein 1, Structural protein MDM1, YM8339.15C, YML104C
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High impact information on MDM1


Biological context of MDM1

  • The MDM1 gene was cloned by complementation, and its sequence revealed an open reading frame encoding a potential protein product of 51.5 kD [3].
  • The mdm1 lesion also retards nuclear division and prevents the transfer of nuclei into the buds [4].
  • The mdm1 and mdm2 mutations are cell-cycle specific, displaying an execution point in late G1 or early S phase [4].

Anatomical context of MDM1


Analytical, diagnostic and therapeutic context of MDM1

  • Antibodies against the MDM1 protein recognized a 51-kD polypeptide that was localized by indirect immunofluorescence to a novel pattern of spots and punctate arrays distributed throughout the yeast cell cytoplasm [3].


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