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Gene Review

ERGIC1  -  endoplasmic reticulum-golgi intermediate...

Homo sapiens

Synonyms: ER-Golgi intermediate compartment 32 kDa protein, ERGIC-32, ERGIC32, Endoplasmic reticulum-Golgi intermediate compartment protein 1, HT034, ...
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Disease relevance of ERGIC1


High impact information on ERGIC1


Biological context of ERGIC1


Anatomical context of ERGIC1


Associations of ERGIC1 with chemical compounds


Physical interactions of ERGIC1

  • The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC [10].

Co-localisations of ERGIC1


Other interactions of ERGIC1


Analytical, diagnostic and therapeutic context of ERGIC1


  1. A mouse cytomegalovirus glycoprotein retains MHC class I complexes in the ERGIC/cis-Golgi compartments. Ziegler, H., Thale, R., Lucin, P., Muranyi, W., Flohr, T., Hengel, H., Farrell, H., Rawlinson, W., Koszinowski, U.H. Immunity (1997) [Pubmed]
  2. Capturing protein interactions in the secretory pathway of living cells. Nyfeler, B., Michnick, S.W., Hauri, H.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. AIDS and its dementia as a neuropeptide disorder: role of VIP receptor blockade by human immunodeficiency virus envelope. Pert, C.B., Smith, C.C., Ruff, M.R., Hill, J.M. Ann. Neurol. (1988) [Pubmed]
  4. Evidence against an essential role of COPII-mediated cargo transport to the endoplasmic reticulum-Golgi intermediate compartment in the formation of the primary membrane of vaccinia virus. Husain, M., Moss, B. J. Virol. (2003) [Pubmed]
  5. Human cytomegalovirus pp28 (UL99) localizes to a cytoplasmic compartment which overlaps the endoplasmic reticulum-golgi-intermediate compartment. Sanchez, V., Sztul, E., Britt, W.J. J. Virol. (2000) [Pubmed]
  6. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Zhang, B., Cunningham, M.A., Nichols, W.C., Bernat, J.A., Seligsohn, U., Pipe, S.W., McVey, J.H., Schulte-Overberg, U., de Bosch, N.B., Ruiz-Saez, A., White, G.C., Tuddenham, E.G., Kaufman, R.J., Ginsburg, D. Nat. Genet. (2003) [Pubmed]
  7. Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. Conrad, P.A., Smart, E.J., Ying, Y.S., Anderson, R.G., Bloom, G.S. J. Cell Biol. (1995) [Pubmed]
  8. Light and electron microscopic localization of presenilin-1 in primate brain. Lah, J.J., Heilman, C.J., Nash, N.R., Rees, H.D., Yi, H., Counts, S.E., Levey, A.I. J. Neurosci. (1997) [Pubmed]
  9. A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum. Pröpsting, M.J., Kanapin, H., Jacob, R., Naim, H.Y. J. Cell. Sci. (2005) [Pubmed]
  10. ERGIC-53 and traffic in the secretory pathway. Hauri, H.P., Kappeler, F., Andersson, H., Appenzeller, C. J. Cell. Sci. (2000) [Pubmed]
  11. Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly. Risco, C., Rodríguez, J.R., López-Iglesias, C., Carrascosa, J.L., Esteban, M., Rodríguez, D. J. Virol. (2002) [Pubmed]
  12. Intracellular targeting signals contribute to localization of coronavirus spike proteins near the virus assembly site. Lontok, E., Corse, E., Machamer, C.E. J. Virol. (2004) [Pubmed]
  13. Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. Breuza, L., Halbeisen, R., Jenö, P., Otte, S., Barlowe, C., Hong, W., Hauri, H.P. J. Biol. Chem. (2004) [Pubmed]
  14. Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells. George, C.H., Kendall, J.M., Campbell, A.K., Evans, W.H. J. Biol. Chem. (1998) [Pubmed]
  15. Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII. Moussalli, M., Pipe, S.W., Hauri, H.P., Nichols, W.C., Ginsburg, D., Kaufman, R.J. J. Biol. Chem. (1999) [Pubmed]
  16. Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme. Vollenweider, F., Kappeler, F., Itin, C., Hauri, H.P. J. Cell Biol. (1998) [Pubmed]
  17. Cholecystokinin-induced anxiety: how is it reflected in studies on exploratory behaviour? Harro, J., Vasar, E. Neuroscience and biobehavioral reviews. (1991) [Pubmed]
  18. Selective accumulation of the endoplasmic reticulum-Golgi intermediate compartment induced by the antitumor drug KRN5500. Kamishohara, M., Kenney, S., Domergue, R., Vistica, D.T., Sausville, E.A. Exp. Cell Res. (2000) [Pubmed]
  19. Oligomerization and interacellular localization of the glycoprotein receptor ERGIC-53 is independent of disulfide bonds. Neve, E.P., Lahtinen, U., Pettersson, R.F. J. Mol. Biol. (2005) [Pubmed]
  20. Expression of caveolin by bovine lymphocytes and antigen-presenting cells. Harris, J., Werling, D., Koss, M., Monaghan, P., Taylor, G., Howard, C.J. Immunology (2002) [Pubmed]
  21. Delta F508 CFTR localizes in the endoplasmic reticulum-Golgi intermediate compartment in cystic fibrosis cells. Gilbert, A., Jadot, M., Leontieva, E., Wattiaux-De Coninck, S., Wattiaux, R. Exp. Cell Res. (1998) [Pubmed]
  22. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Kask, A., Harro, J., von Hörsten, S., Redrobe, J.P., Dumont, Y., Quirion, R. Neuroscience and biobehavioral reviews. (2002) [Pubmed]
  23. Altered expression of beta-catenin/E-cadherin in meningiomas. Brunner, E.C., Romeike, B.F., Jung, M., Comtesse, N., Meese, E. Histopathology (2006) [Pubmed]
  24. Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking. Hatsuzawa, K., Hirose, H., Tani, K., Yamamoto, A., Scheller, R.H., Tagaya, M. J. Biol. Chem. (2000) [Pubmed]
  25. VIPL, a VIP36-like membrane protein with a putative function in the export of glycoproteins from the endoplasmic reticulum. Neve, E.P., Svensson, K., Fuxe, J., Pettersson, R.F. Exp. Cell Res. (2003) [Pubmed]
  26. A novel mechanism for mitogen-activated protein kinase localization. Bind, E., Kleyner, Y., Skowronska-Krawczyk, D., Bien, E., Dynlacht, B.D., Sánchez, I. Mol. Biol. Cell (2004) [Pubmed]
  27. The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. Greenfield, J.J., High, S. J. Cell. Sci. (1999) [Pubmed]
  28. Lumenal targeted GFP, used as a marker of soluble cargo, visualises rapid ERGIC to Golgi traffic by a tubulo-vesicular network. Blum, R., Stephens, D.J., Schulz, I. J. Cell. Sci. (2000) [Pubmed]
  29. TbRab2p, a marker for the endoplasmic reticulum of Trypanosoma brucei, localises to the ERGIC in mammalian cells. Field, H., Ali, B.R., Sherwin, T., Gull, K., Croft, S.L., Field, M.C. J. Cell. Sci. (1999) [Pubmed]
  30. The recycling pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment. Klumperman, J., Schweizer, A., Clausen, H., Tang, B.L., Hong, W., Oorschot, V., Hauri, H.P. J. Cell. Sci. (1998) [Pubmed]
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