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Gene Review

SPO20  -  Spo20p

Saccharomyces cerevisiae S288c

Synonyms: Sporulation-specific protein 20, YM9711.05, YMR017W
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High impact information on SPO20

  • Although there are numerous homologues of syntaxin on intracellular membranes, there are only two SNAP-25-related proteins in yeast, Sec9 and Spo20, both of which are localized to the plasma membrane and function in secretion and sporulation, respectively [1].
  • In Saccharomyces cerevisiae, the developmentally regulated Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) protein Spo20p mediates the fusion of vesicles with the prospore membrane, which is required for the formation of spores [2].
  • Consistent with this, deletion of KES1, a gene that behaves as a negative regulator of SPO14, also promotes the function of SPO20 in vegetative cells [3].
  • Suppression by MSS4 is specific to molecules that contain the Spo20p helical domains [3].
  • A chimeric molecule, in which the helices of Sec9p that bind to Sso1/2p and Snc1/2p are replaced with the homologous regions of Spo20p, will not support vesicle fusion in vegetative cells [3].

Biological context of SPO20

  • A similar phenotype was seen when the t-SNARE Sso1p, or the partially redundant t-SNAREs Sec9p and Spo20p were mutated [4].

Associations of SPO20 with chemical compounds

  • These results indicate that elevated levels of phosphatidic acid in the membrane may be required specifically for the function of SNARE complexes containing Spo20p [3].

Other interactions of SPO20

  • SEC9 and SPO20 encode SNARE proteins related to the mammalian SNAP-25 family [3].


  1. Functional architecture of an intracellular membrane t-SNARE. Fukuda, R., McNew, J.A., Weber, T., Parlati, F., Engel, T., Nickel, W., Rothman, J.E., Söllner, T.H. Nature (2000) [Pubmed]
  2. Positive and negative regulation of a SNARE protein by control of intracellular localization. Nakanishi, H., de los Santos, P., Neiman, A.M. Mol. Biol. Cell (2004) [Pubmed]
  3. Genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae. Coluccio, A., Malzone, M., Neiman, A.M. Genetics (2004) [Pubmed]
  4. Phospholipase D and the SNARE Sso1p are necessary for vesicle fusion during sporulation in yeast. Nakanishi, H., Morishita, M., Schwartz, C.L., Coluccio, A., Engebrecht, J., Neiman, A.M. J. Cell. Sci. (2006) [Pubmed]
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