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Gene Review

MSS4  -  1-phosphatidylinositol-4-phosphate 5-kinase

Saccharomyces cerevisiae S288c

Synonyms: 1-phosphatidylinositol 4-phosphate kinase, Diphosphoinositide kinase, PIP5K, YD8142A.05, YDR208W
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Disease relevance of MSS4


High impact information on MSS4


Biological context of MSS4


Anatomical context of MSS4

  • These results suggest that MSS4 is the major PI(4)P 5-kinase in yeast and provide a link between phosphoinositide metabolism and organization of the actin cytoskeleton in vivo [7].
  • The presence of dibasic residues at the C-terminal end of KHD was conserved among mammalian as well as invertebrate PIP5K family members, but not in the type II PIPKs that are not targeted to the plasma membrane, suggesting that the conserved dibasic motif provides a mechanism essential for the proper localization and cellular function of PIP5Ks [10].

Associations of MSS4 with chemical compounds


Other interactions of MSS4

  • Surprisingly, overexpression of PLC1 and MSS4 also suppressed the growth defect of a class B mutant [12].
  • Suppression by MSS4 is specific to molecules that contain the Spo20p helical domains [13].
  • Based on genetic and biochemical data, we suggest that MSS4 acts downstream of STT4, but in a pathway that does not involve PKC1 [6].

Analytical, diagnostic and therapeutic context of MSS4

  • The existence of a PIP5K family of enzymes has been suggested by Western blotting and purification of numerous PIP5Ks from various tissues and cell types [14].
  • In cell cultures, overexpression of Type I PIP5-kinase specifically increases PIP(2), whereas overexpression of Type II PI4-kinase can increase both PIP and PIP(2) [15].


  1. The sequence of phosphatidylinositol-4-phosphate 5-kinase defines a novel family of lipid kinases. Boronenkov, I.V., Anderson, R.A. J. Biol. Chem. (1995) [Pubmed]
  2. Friedreich's ataxia: a defect in signal transduction? Carvajal, J.J., Pook, M.A., Doudney, K., Hillermann, R., Wilkes, D., al-Mahdawi, S., Williamson, R., Chamberlain, S. Hum. Mol. Genet. (1995) [Pubmed]
  3. Disturbance of sphingolipid biosynthesis abrogates the signaling of Mss4, phosphatidylinositol-4-phosphate 5-kinase, in yeast. Kobayashi, T., Takematsu, H., Yamaji, T., Hiramoto, S., Kozutsumi, Y. J. Biol. Chem. (2005) [Pubmed]
  4. The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Stefan, C.J., Audhya, A., Emr, S.D. Mol. Biol. Cell (2002) [Pubmed]
  5. Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. Homma, K., Terui, S., Minemura, M., Qadota, H., Anraku, Y., Kanaho, Y., Ohya, Y. J. Biol. Chem. (1998) [Pubmed]
  6. Genetic interactions among genes involved in the STT4-PKC1 pathway of Saccharomyces cerevisiae. Yoshida, S., Ohya, Y., Nakano, A., Anraku, Y. Mol. Gen. Genet. (1994) [Pubmed]
  7. MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. Desrivières, S., Cooke, F.T., Parker, P.J., Hall, M.N. J. Biol. Chem. (1998) [Pubmed]
  8. Phosphatidylinositol-4-phosphate 5-kinase activity is stimulated during temperature-induced morphogenesis in Candida albicans. Hairfield, M.L., Westwater, C., Dolan, J.W. Microbiology (Reading, Engl.) (2002) [Pubmed]
  9. An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors. Elge, S., Brearley, C., Xia, H.J., Kehr, J., Xue, H.W., Mueller-Roeber, B. Plant J. (2001) [Pubmed]
  10. Dibasic amino acid residues at the carboxy-terminal end of kinase homology domain participate in the plasma membrane localization and function of phosphatidylinositol 5-kinase gamma. Arioka, M., Nakashima, S., Shibasaki, Y., Kitamoto, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  11. STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. Cutler, N.S., Heitman, J., Cardenas, M.E. J. Biol. Chem. (1997) [Pubmed]
  12. TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Helliwell, S.B., Howald, I., Barbet, N., Hall, M.N. Genetics (1998) [Pubmed]
  13. Genetic evidence of a role for membrane lipid composition in the regulation of soluble NEM-sensitive factor receptor function in Saccharomyces cerevisiae. Coluccio, A., Malzone, M., Neiman, A.M. Genetics (2004) [Pubmed]
  14. The phosphatidylinositol 4-phosphate 5-kinase family. Loijens, J.C., Boronenkov, I.V., Parker, G.J., Anderson, R.A. Adv. Enzyme Regul. (1996) [Pubmed]
  15. Nonradioactive analysis of phosphatidylinositides and other anionic phospholipids by anion-exchange high-performance liquid chromatography with suppressed conductivity detection. Nasuhoglu, C., Feng, S., Mao, J., Yamamoto, M., Yin, H.L., Earnest, S., Barylko, B., Albanesi, J.P., Hilgemann, D.W. Anal. Biochem. (2002) [Pubmed]
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