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Gene Review

ISF1  -  Isf1p

Saccharomyces cerevisiae S288c

Synonyms: Increasing suppression factor 1, MBR3, Mitochondrial biogenesis regulation protein 3, YM9582.06C, YMR081C
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High impact information on ISF1

  • We propose that NAM7 is under the control of a negative Cyp1p-dependent regulator and that its absence favours a transcriptional read-through which results in the ISF1-NAM7 cotranscript we have identified [1].
  • The ISF1 gene is not essential for cell viability or respiratory growth [2].
  • We propose that ISF1 could influence the NAM7/UPF1 function, possibly at the level of mRNA turnover, thus modulating the expression of nuclear genes involved in mitochondrial biogenesis [2].
  • However as for many mitochondrial genes, ISF1 expression is sensitive to fermentative repression; in contrast expression of the NAM7 gene is unaffected by glucose [2].
  • Disruption of MBR3 has no major effect but the double disruptant shows a synthetic phenotype suggesting that the MBR1 and MBR3 gene products participate in common function [3].

Other interactions of ISF1

  • Nucleotide sequencing of MBR1 and MBR3 revealed that these two genes encode serine-rich, hydrophilic proteins with regions of significant homology [3].


  1. The transcription of NAM7/UPF1 is enhanced in the absence of Cyp1p/Hap1p concomitant with the appearance of an ISF1-NAM7 cotranscript in Saccharomyces cerevisiae. Altamura, N., de Pinto, B., Castaldo, R., Verdiére, J. FEBS Lett. (1997) [Pubmed]
  2. Two adjacent nuclear genes, ISF1 and NAM7/UPF1, cooperatively participate in mitochondrial functions in Saccharomyces cerevisiae. Altamura, N., Dujardin, G., Groudinsky, O., Slonimski, P.P. Mol. Gen. Genet. (1994) [Pubmed]
  3. MBR1 and MBR3, two related yeast genes that can suppress the growth defect of hap2, hap3 and hap4 mutants. Daignan-Fornier, B., Nguyen, C.C., Reisdorf, P., Lemeignan, B., Bolotin-Fukuhara, M. Mol. Gen. Genet. (1994) [Pubmed]
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