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Gene Review

TIR1  -  Tir1p

Saccharomyces cerevisiae S288c

Synonyms: Cold shock-induced protein TIR1, SRP1, Serine-rich protein 1, TIP1-related protein 1, YER011W
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High impact information on TIR1


Biological context of TIR1


Anatomical context of TIR1

  • The hypoxic SRP1/TIR1 gene encodes a stress-response cell wall mannoprotein and this gene is downregulated at acidic pH [10].

Associations of TIR1 with chemical compounds

  • The hypoxic SRP1/TIR1 gene encodes a stress-response cell wall mannoprotein, which is shown to be necessary for yeast growth at acidic pH in the presence of sodium dodecyl sulfate [11].
  • The cDNA sequence encoding Nopp52 predicts a polypeptide whose amino-terminal half consists of multiple acidic/serine-rich regions alternating with basic/proline-rich regions [12].
  • An amino-terminal domain containing a signal sequence and a carboxy-terminal domain with homology to GPI (glycosyl-phosphatidyl-inositol) anchor-containing proteins are separated by a central domain containing a highly repeated threonine- and serine-rich sequence [13].
  • However, both plant SR proteins are rich in proline, and SR45, unlike most animal SR proteins, has two distinct arginine/serine-rich domains separated by an RNA recognition motif [14].
  • In addition to the RING-H2 motif, the predicted protein has a C4 zinc finger, an acidic region, a glycine-rich cluster, and a serine-rich cluster [15].

Other interactions of TIR1

  • Thus, cAMP allows partial relief of the TIR1 repression exerted by Ord1p [10].
  • However, unlike known HOG pathway-dependent genes, TIR1 is under positive cAMP control and this effect is mediated by GPA2 but not by RAS2 [10].
  • The predicted protein sequence of TIR2 demonstrates remarkable homology to TIR1 (72.2%) and is also homologous with TIP1 (49%) [16].
  • Disruptions of TIR1, TIR3, or TIR4 prevent anaerobic growth, indicating that each protein is essential for anaerobic adaptation [17].
  • We found that a pmt1 deletion mutant was highly sensitive to zymolyase and that in this strain the alpha-galactosidase-Srp1 fusion proteins, an alpha-galactosidase-Sed1 hybrid protein and an alpha-galactosidase-alpha-agglutinin hybrid protein were absent from both the membrane and the cell wall fractions [18].


  1. Multiple regions of NSR1 are sufficient for accumulation of a fusion protein within the nucleolus. Yan, C., Mélèse, T. J. Cell Biol. (1993) [Pubmed]
  2. Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. Lee, C.Q., Yun, Y.D., Hoeffler, J.P., Habener, J.F. EMBO J. (1990) [Pubmed]
  3. CDC68, a yeast gene that affects regulation of cell proliferation and transcription, encodes a protein with a highly acidic carboxyl terminus. Rowley, A., Singer, R.A., Johnston, G.C. Mol. Cell. Biol. (1991) [Pubmed]
  4. Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae. Marshall, M., Mahoney, D., Rose, A., Hicks, J.B., Broach, J.R. Mol. Cell. Biol. (1987) [Pubmed]
  5. A Rox1-independent hypoxic pathway in yeast. Antagonistic action of the repressor Ord1 and activator Yap1 for hypoxic expression of the SRP1/TIR1 gene. Bourdineaud, J.P., De Sampaïo, G., Lauquin, G.J. Mol. Microbiol. (2000) [Pubmed]
  6. Yeast gene SRP1 (serine-rich protein). Intragenic repeat structure and identification of a family of SRP1-related DNA sequences. Marguet, D., Guo, X.J., Lauquin, G.J. J. Mol. Biol. (1988) [Pubmed]
  7. Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Tang, Z., Käufer, N.F., Lin, R.J. Biochem. J. (2002) [Pubmed]
  8. Seripauperins of Saccharomyces cerevisiae: a new multigene family encoding serine-poor relatives of serine-rich proteins. Viswanathan, M., Muthukumar, G., Cong, Y.S., Lenard, J. Gene (1994) [Pubmed]
  9. Identification and analysis of a static culture-specific cell wall protein, Tir1p/Srp1p in Saccharomyces cerevisiae. Kitagaki, H., Shimoi, H., Itoh, K. Eur. J. Biochem. (1997) [Pubmed]
  10. At acidic pH, the GPA2-cAMP pathway is necessary to counteract the ORD1-mediated repression of the hypoxic SRP1/TIR1 yeast gene. Bourdineaud, J.P. Yeast (2001) [Pubmed]
  11. At acidic pH, the diminished hypoxic expression of the SRP1/TIR1 yeast gene depends on the GPA2-cAMP and HOG pathways. Bourdineaud, J.P. Res. Microbiol. (2000) [Pubmed]
  12. An abundant nucleolar phosphoprotein is associated with ribosomal DNA in Tetrahymena macronuclei. McGrath, K.E., Smothers, J.F., Dadd, C.A., Madireddi, M.T., Gorovsky, M.A., Allis, C.D. Mol. Biol. Cell (1997) [Pubmed]
  13. FLO11, a yeast gene related to the STA genes, encodes a novel cell surface flocculin. Lo, W.S., Dranginis, A.M. J. Bacteriol. (1996) [Pubmed]
  14. An SC35-like protein and a novel serine/arginine-rich protein interact with Arabidopsis U1-70K protein. Golovkin, M., Reddy, A.S. J. Biol. Chem. (1999) [Pubmed]
  15. The RING finger motif of photomorphogenic repressor COP1 specifically interacts with the RING-H2 motif of a novel Arabidopsis protein. Torii, K.U., Stoop-Myer, C.D., Okamoto, H., Coleman, J.E., Matsui, M., Deng, X.W. J. Biol. Chem. (1999) [Pubmed]
  16. Cold-shock induction of a family of TIP1-related proteins associated with the membrane in Saccharomyces cerevisiae. Kowalski, L.R., Kondo, K., Inouye, M. Mol. Microbiol. (1995) [Pubmed]
  17. Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. Abramova, N., Sertil, O., Mehta, S., Lowry, C.V. J. Bacteriol. (2001) [Pubmed]
  18. Pmt1 mannosyl transferase is involved in cell wall incorporation of several proteins in Saccharomyces cerevisiae. Bourdineaud, J.P., van der Vaart, J.M., Donzeau, M., de Sampaïo, G., Verrips, C.T., Lauquin, G.J. Mol. Microbiol. (1998) [Pubmed]
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