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Gene Review

REC114  -  Rec114p

Saccharomyces cerevisiae S288c

Synonyms: Meiotic recombination protein REC114, YM9375.02, YMR133W
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High impact information on REC114

  • We have also found that the Mei4 and Rec114 proteins localize to foci on chromosomes and these foci partially colocalize with each other and with Mer2 [1].
  • Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation [1].
  • Some of the observed phenotypes of the disruption mutant and the N-terminal sequence homology suggest that Rec7p is a functional homolog of Rec114p of Saccharomyces cerevisiae [2].
  • The low viability of spores produced by dmc1 mutants carrying high copy numbers of REC114 is rescued when reductional segregation is bypassed by mutation of spo13 [3].
  • The splicing of REC114 does not require MER1, a gene known to be involved in meiosis-specific RNA processing [4].

Biological context of REC114

  • This work demonstrates that REC114 does have an intron and is one of only three genes in yeast with introns located in the 3' end [4].
  • One of these genes, REC114, is described here, and the data confirm that REC114 is a meiosis-specific recombination gene with no detectable function in mitosis [5].

Other interactions of REC114


  1. Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation. Li, J., Hooker, G.W., Roeder, G.S. Genetics (2006) [Pubmed]
  2. Characterization of rec7, an early meiotic recombination gene in Schizosaccharomyces pombe. Molnar, M., Parisi, S., Kakihara, Y., Nojima, H., Yamamoto, A., Hiraoka, Y., Bozsik, A., Sipiczki, M., Kohli, J. Genetics (2001) [Pubmed]
  3. High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway. Bishop, D.K., Nikolski, Y., Oshiro, J., Chon, J., Shinohara, M., Chen, X. Genes Cells (1999) [Pubmed]
  4. Examination of the intron in the meiosis-specific recombination gene REC114 in Saccharomyces. Malone, R.E., Pittman, D.L., Nau, J.J. Mol. Gen. Genet. (1997) [Pubmed]
  5. Genetic and molecular analysis of REC114, an early meiotic recombination gene in yeast. Pittman, D., Lu, W., Malone, R.E. Curr. Genet. (1993) [Pubmed]
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