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Gene Review

YHM2  -  Yhm2p

Saccharomyces cerevisiae S288c

Synonyms: Citrate/oxoglutarate carrier protein, Coc1p, Mitochondrial DNA replication protein YHM2, YM9408.03, YMR241W
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High impact information on YHM2

  • To better understand the role of Abf2p in the maintenance of the mitochondrial chromosome, we have isolated a multicopy suppressor (YHM2) of the temperature-sensitive defect associated with an abf2 null mutation [1].
  • Disruption of YHM2 causes a significant growth defect in the presence of nonfermentable carbon sources such as glycerol and ethanol, and the cells have defects in respiration as determined by 2,3,5,-triphenyltetrazolium chloride staining [1].
  • Yhm2p has 314 amino acid residues, and the deduced amino acid sequence is similar to that of a family of mitochondrial carrier proteins [1].
  • Yhm2p may function as a member of the protein machinery for the mitochondrial inner membrane attachment site of mitochondrial DNA during replication and segregation of mitochondrial genomes [1].

Regulatory relationships of YHM2

  • A sequence that is similar to the HMG DNA-binding domain is important for the DNA-binding activity of Yhm2p, and a mutation in this region abolishes the ability of YHM2 to suppress the temperature-sensitive defect of respiration of the abf2 null mutant [1].


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