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Gene Review

FIG4  -  phosphatidylinositol-3,5-bisphosphate 5...

Saccharomyces cerevisiae S288c

Synonyms: Factor-induced gene 4 protein, N0330, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, Polyphosphoinositide phosphatase, YNL325C
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High impact information on FIG4

  • Synthesis is catalyzed by the PI3P 5-kinase Fab1p, and turnover is catalyzed by the PI3,5P2 5-phosphatase Fig4p [1].
  • Three of the proteins encoded by these genes, Fig1p, Fig2p, and Fig4p, are dispensible for cell polarization in uniform concentrations of mating pheromone, but are required for normal cell polarization in mating mixtures, conditions that involve cell-cell communication [2].
  • Fig4p is a member of a family of eukaryotic proteins that contain a domain homologous to the yeast Sac1p [2].
  • Consistent with these observations, we found that Fig4 physically associates with Vac14 in a common membrane-associated complex [3].
  • More recently, a suppressor of vac7Delta mutants was identified and shown to encode a putative phosphoinositide phosphatase, Fig4 [3].

Biological context of FIG4


Anatomical context of FIG4

  • Analysis of a Fig4-GFP fusion protein revealed that the Fig4 phosphatase is localized to the limiting membrane of the vacuole [3].

Other interactions of FIG4

  • Our studies indicate that Vac14 both positively regulates Fab1 kinase activity and directs the localization/activation of the Fig4 PtdIns(3,5)P2 phosphatase [3].


  1. The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. Duex, J.E., Tang, F., Weisman, L.S. J. Cell Biol. (2006) [Pubmed]
  2. Pheromone-regulated genes required for yeast mating differentiation. Erdman, S., Lin, L., Malczynski, M., Snyder, M. J. Cell Biol. (1998) [Pubmed]
  3. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Rudge, S.A., Anderson, D.M., Emr, S.D. Mol. Biol. Cell (2004) [Pubmed]
  4. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S., Emr, S.D. Mol. Biol. Cell (2002) [Pubmed]
  5. Three SAC1-like genes show overlapping patterns of expression in Arabidopsis but are remarkably silent during embryo development. Despres, B., Bouissonnié, F., Wu, H.J., Gomord, V., Guilleminot, J., Grellet, F., Berger, F., Delseny, M., Devic, M. Plant J. (2003) [Pubmed]
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