Gene Review:
FAB1 - 1-phosphatidylinositol-3-phosphate 5-kinase
Saccharomyces cerevisiae S288c
Synonyms:
1-phosphatidylinositol 3-phosphate 5-kinase FAB1, PIPkin-III, Phosphatidylinositol 3-phosphate 5-kinase, Type III PIP kinase, YFR019W
- Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body. Odorizzi, G., Babst, M., Emr, S.D. Cell (1998)
- The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Efe, J.A., Botelho, R.J., Emr, S.D. Curr. Opin. Cell Biol. (2005)
- Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body. Dove, S.K., McEwen, R.K., Mayes, A., Hughes, D.C., Beggs, J.D., Michell, R.H. Curr. Biol. (2002)
- PtdIns(3,5)P2 is required for delivery of endocytic cargo into the multivesicular body. Shaw, J.D., Hama, H., Sohrabi, F., DeWald, D.B., Wendland, B. Traffic (2003)
- Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary, J.D., Wurmser, A.E., Bonangelino, C.J., Weisman, L.S., Emr, S.D. J. Cell Biol. (1998)
- Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. Dove, S.K., Piper, R.C., McEwen, R.K., Yu, J.W., King, M.C., Hughes, D.C., Thuring, J., Holmes, A.B., Cooke, F.T., Michell, R.H., Parker, P.J., Lemmon, M.A. EMBO J. (2004)
- Phosphatidylinositol-4-phosphate 5-kinase localized on the plasma membrane is essential for yeast cell morphogenesis. Homma, K., Terui, S., Minemura, M., Qadota, H., Anraku, Y., Kanaho, Y., Ohya, Y. J. Biol. Chem. (1998)
- The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans. Nicot, A.S., Fares, H., Payrastre, B., Chisholm, A.D., Labouesse, M., Laporte, J. Mol. Biol. Cell (2006)
- Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S., Emr, S.D. Mol. Biol. Cell (2002)
- Phosphoinositide signaling: vac to the future in fab1 kinase regulation. DeWald, D.B. Curr. Biol. (2002)
- Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Bonangelino, C.J., Catlett, N.L., Weisman, L.S. Mol. Cell. Biol. (1997)
- Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast. Yamamoto, A., DeWald, D.B., Boronenkov, I.V., Anderson, R.A., Emr, S.D., Koshland, D. Mol. Biol. Cell (1995)
- Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Rudge, S.A., Anderson, D.M., Emr, S.D. Mol. Biol. Cell (2004)
- Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Katzmann, D.J., Sarkar, S., Chu, T., Audhya, A., Emr, S.D. Mol. Biol. Cell (2004)