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Gene Review: 

NAM9  -  mitochondrial 37S ribosomal protein NAM9

Saccharomyces cerevisiae S288c

Synonyms: 37S ribosomal protein NAM9, mitochondrial, MNA6, N1211, N1840, Nuclear accommodation of mitochondria protein 9, ...
 
 
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Disease relevance of NAM9

  • The nuclear gene NAM9 from Saccharomyces cerevisiae (Sc) codes for a protein which, on the basis of sequence homology, was previously postulated to be a mitochondrial (mt) equivalent of the Escherichia coli (Ec) S4 ribosomal protein (r-protein) [Boguta et al., Mol. Cell. Biol. 12 (1992) 402-412] [1].
 

High impact information on NAM9

  • Nam9p is a protein of the mitochondrial ribosome [2].
  • Orthogonal-field alternation gel electrophoresis analysis and genetic mapping localized the NAM9 gene on the right arm of chromosome XIV [3].
  • The mt-r character of the NAM9 product is now confirmed by cross-reaction with the antisera for the Sc mt r-proteins [1].
  • The levels of the NAM9 transcript and protein are both reduced in cells growing on glucose as compared to cells growing on galactose as a carbon source [4].
  • Increase in NAM9 gene dosage is accompanied by the increase in both mRNA and protein [4].
 

Analytical, diagnostic and therapeutic context of NAM9

  • Sequence analysis of the NAM9 gene showed that it encodes a basic protein of 485 amino acids with a presequence that could target the protein to the mitochondrial matrix [3].
  • We report the genetic characterization, molecular cloning, and sequencing of a novel nuclear suppressor, the NAM9 gene from Saccharomyces cerevisiae, which acts on mutations of mitochondrial DNA [3].

References

  1. The NAM9-1 suppressor mutation in a nuclear gene encoding ribosomal mitochondrial protein of Saccharomyces cerevisiae. Dmochowska, A., Konopińska, A., Krzymowska, M., Szcześniak, B., Boguta, M. Gene (1995) [Pubmed]
  2. Prion-dependent switching between respiratory competence and deficiency in the yeast nam9-1 mutant. Chacinska, A., Boguta, M., Krzewska, J., Rospert, S. Mol. Cell. Biol. (2000) [Pubmed]
  3. NAM9 nuclear suppressor of mitochondrial ochre mutations in Saccharomyces cerevisiae codes for a protein homologous to S4 ribosomal proteins from chloroplasts, bacteria, and eucaryotes. Boguta, M., Dmochowska, A., Borsuk, P., Wrobel, K., Gargouri, A., Lazowska, J., Slonimski, P.P., Szczesniak, B., Kruszewska, A. Mol. Cell. Biol. (1992) [Pubmed]
  4. Expression of the yeast NAM9 gene coding for mitochondrial ribosomal protein. Boguta, M., Chacińska, A., Murawski, M., Szcześniak, B. Acta Biochim. Pol. (1997) [Pubmed]
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