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Gene Review

VAC7  -  Vac7p

Saccharomyces cerevisiae S288c

Synonyms: N2467, Vacuolar segregation protein 7, YNL054W, YNL2467W
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High impact information on VAC7

  • In both the absence and presence of Vac7p, the Vac14p-Fig4p complex controls the hyperosmotic shock-induced increase in PI3,5P2 levels [1].
  • The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover [1].
  • Interestingly, deletion of VAC7 also results in an enlarged vacuole morphology and has no detectable PtdIns(3,5)P2, suggesting that Vac7p functions as an upstream regulator, perhaps in a complex with Fab1p [2].
  • VAC7 encodes a novel 128-kDa protein that is localized at the vacuole membrane [3].
  • VAC7 encodes a 128-kDa transmembrane protein that localizes to vacuolar membranes [4].

Biological context of VAC7

  • Surprisingly, despite the apparent lack of quantitative vacuolar inheritance, all daughter cells of vac6 and vac7 had obtained a vacuole before cell division [5].

Anatomical context of VAC7

  • Both vac7 and fab1 null mutants have dramatically enlarged vacuoles and cannot grow at elevated temperatures [4].

Associations of VAC7 with chemical compounds

  • In the BY4742 genetic background, loss of Vac14 causes much more penetrant effects on phosphoinositide metabolism and vacuolar trafficking than does loss of Vac7, another regulator of Fab1 [6].

Regulatory relationships of VAC7

  • Genetic studies have indicated that Fab1 kinase is positively regulated by Vac7 and Vac14; deletion of either gene results in ablation of PtdIns(3,5)P2 synthesis and the formation of a grossly enlarged vacuole [7].

Other interactions of VAC7

  • Additionally, vac7Delta mutants have nearly undetectable levels of PtdIns(3,5)P(2), suggesting that Vac7 functions to regulate Fab1 kinase activity [4].


  1. The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. Duex, J.E., Tang, F., Weisman, L.S. J. Cell Biol. (2006) [Pubmed]
  2. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary, J.D., Wurmser, A.E., Bonangelino, C.J., Weisman, L.S., Emr, S.D. J. Cell Biol. (1998) [Pubmed]
  3. Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Bonangelino, C.J., Catlett, N.L., Weisman, L.S. Mol. Cell. Biol. (1997) [Pubmed]
  4. Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S., Emr, S.D. Mol. Biol. Cell (2002) [Pubmed]
  5. Characterization of new vacuolar segregation mutants, isolated by screening for loss of proteinase B self-activation. Gomes de Mesquita, D.S., van den Hazel, H.B., Bouwman, J., Woldringh, C.L. Eur. J. Cell Biol. (1996) [Pubmed]
  6. Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body. Dove, S.K., McEwen, R.K., Mayes, A., Hughes, D.C., Beggs, J.D., Michell, R.H. Curr. Biol. (2002) [Pubmed]
  7. Vacuole size control: regulation of PtdIns(3,5)P2 levels by the vacuole-associated Vac14-Fig4 complex, a PtdIns(3,5)P2-specific phosphatase. Rudge, S.A., Anderson, D.M., Emr, S.D. Mol. Biol. Cell (2004) [Pubmed]
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