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Gene Review

BBP1  -  Bbp1p

Saccharomyces cerevisiae S288c

Synonyms: BFR1-binding protein 1, P0745, Spindle pole component BBP1, YPL255W
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High impact information on BBP1

  • Here, we describe the identification of BBP1 in a suppressor screen with a conditional lethal allele of SPC29 [1].
  • Importantly, these cells exhibit a "dead" SPB phenotype, similar to cells mutant in MPS2, NDC1, or BBP1 [2].
  • Tetraploid yeast cells lacking BFR1 or overexpressing an essential gene BBP1 produce a novel type of ascus that contains asci instead of spores [3].

Biological context of BBP1


  1. The Bbp1p-Mps2p complex connects the SPB to the nuclear envelope and is essential for SPB duplication. Schramm, C., Elliott, S., Shevchenko, A., Schiebel, E. EMBO J. (2000) [Pubmed]
  2. The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p. Araki, Y., Lau, C.K., Maekawa, H., Jaspersen, S.L., Giddings, T.H., Schiebel, E., Winey, M. Mol. Biol. Cell (2006) [Pubmed]
  3. Yeast mutants that produce a novel type of ascus containing asci instead of spores. Xue, Z., Shan, X., Sinelnikov, A., Mélèse, T. Genetics (1996) [Pubmed]
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