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Gene Review

BFR1  -  Bfr1p

Saccharomyces cerevisiae S288c

Synonyms: Brefeldin A resistance protein 1, Nuclear segregation protein BFR1, YOR198C
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Disease relevance of BFR1


High impact information on BFR1

  • Tetraploid yeast cells lacking BFR1 or overexpressing an essential gene BBP1 produce a novel type of ascus that contains asci instead of spores [2].
  • Bfr1p and Bbp1p interact with each other in a two hybrid assay, further suggesting that they might form a complex important for cell cycle coordination [2].
  • Cells depleted of Bbp1p or lacking Bfr1p are defective in a number of processes such as nuclear segregation, bud formation, cytokinesis and nuclear spindle formation [2].
  • BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae [3].
  • A bfr1-delta 1::URA3 deletion strain is viable, but has defects in cell morphology and nuclear segregation, and the mutation accentuates the growth and secretion defects of a sec21 mutant [3].

Biological context of BFR1


Anatomical context of BFR1


  1. bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily. Nagao, K., Taguchi, Y., Arioka, M., Kadokura, H., Takatsuki, A., Yoda, K., Yamasaki, M. J. Bacteriol. (1995) [Pubmed]
  2. Yeast mutants that produce a novel type of ascus containing asci instead of spores. Xue, Z., Shan, X., Sinelnikov, A., Mélèse, T. Genetics (1996) [Pubmed]
  3. BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae. Jackson, C.L., Képès, F. Genetics (1994) [Pubmed]
  4. Scp160p, a multiple KH-domain protein, is a component of mRNP complexes in yeast. Lang, B.D., Fridovich-Keil, J.L. Nucleic Acids Res. (2000) [Pubmed]
  5. The brefeldin A resistance protein Bfr1p is a component of polyribosome-associated mRNP complexes in yeast. Lang, B.D., Li Am, n.u.l.l., Black-Brewster, H.D., Fridovich-Keil, J.L. Nucleic Acids Res. (2001) [Pubmed]
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