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Gene Review

VIK1  -  Vik1p

Saccharomyces cerevisiae S288c

Synonyms: Spindle pole body-associated protein VIK1, Vegetative interaction with KAR3 protein 1, YPL253C
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High impact information on VIK1

  • Kinesin kar3 and vik1 go head to head [1].
  • However, this does not hinder movement of the heterodimer because other features of the remarkably divergent Vik1 motor domain are retained, including the ability to bind microtubules [1].
  • Vik1 Modulates Microtubule-Kar3 Interactions through a Motor Domain that Lacks an Active Site [2].
  • We have identified a Saccharomyces cerevisiae gene, named VIK1, encoding a protein with sequence and structural similarity to Cik1p [3].
  • This loss in viability is partially attributable to vegetative chromosome loss in vik1 diploids [4].

Biological context of VIK1

  • These data are consistent with the model that Cik1p is necessary for some, but not all, of the roles of Kar3p in meiosis I. vik1 mutants sporulate at wild-type levels, but have reduced spore viability [4].
  • Cik1p and Vik1p are kinesin-associated proteins known to modulate the function of Kar3p in the microtubule-dependent processes of karyogamy and mitosis [4].

Anatomical context of VIK1

  • Disruption of VIK1 causes increased resistance to the microtubule depolymerizing drug benomyl and partially suppresses growth defects of cik1Delta mutants [3].

Other interactions of VIK1

  • Vik1p localizes to the spindle-pole body region in a Kar3p-dependent manner [3].


  1. Kinesin kar3 and vik1 go head to head. Woehlke, G., Schliwa, M. Cell (2007) [Pubmed]
  2. Vik1 Modulates Microtubule-Kar3 Interactions through a Motor Domain that Lacks an Active Site. Allingham, J.S., Sproul, L.R., Rayment, I., Gilbert, S.P. Cell (2007) [Pubmed]
  3. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. Manning, B.D., Barrett, J.G., Wallace, J.A., Granok, H., Snyder, M. J. Cell Biol. (1999) [Pubmed]
  4. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Shanks, R.M., Kamieniecki, R.J., Dawson, D.S. Genetics (2001) [Pubmed]
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