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Gene Review

CIK1  -  Cik1p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome instability and karyogamy protein 1, Spindle pole body-associated protein CIK1, YM9646.11, YMR198W
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High impact information on CIK1


Biological context of CIK1


Anatomical context of CIK1

  • The Cik1p::beta-gal fusion does not localize to the SPB or microtubules in a kar3 delta strain, and the Kar3p::beta-gal fusion protein does not localize to microtubule-associated structures in a cik1 delta strain [8].

Associations of CIK1 with chemical compounds


Other interactions of CIK1

  • Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein [8].
  • Consistent with its mutant phenotype, we found that the kar4 mutation resulted in failure to induce KAR3 and CIK1 mRNA during mating [6].
  • ROM2 and RHO2 were identified in a screen for high-copy number suppressors of cik1 delta, a mutant defective in microtubule-based processes in Saccharomyces cerevisiae [10].

Analytical, diagnostic and therapeutic context of CIK1

  • Analysis by both the two-hybrid system and co-immunoprecipitation experiments indicates that Cik1p and kar3p interact, suggesting that they are part of the same protein complex [8].
  • The dependence of Cik1p and Kar3p localization upon one another was investigated by indirect immunofluorescence of fusion proteins in pheromone-treated cells [8].
  • Sequence analysis of the CIK1 gene predicts that the CIK1 protein is 594 amino acids in length and possesses a central 300-amino-acid coiled-coil domain [1].


  1. CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae. Page, B.D., Snyder, M. Genes Dev. (1992) [Pubmed]
  2. Kar3 interaction with Cik1 alters motor structure and function. Chu, H.M., Yun, M., Anderson, D.E., Sage, H., Park, H.W., Endow, S.A. EMBO J. (2005) [Pubmed]
  3. Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. Manning, B.D., Barrett, J.G., Wallace, J.A., Granok, H., Snyder, M. J. Cell Biol. (1999) [Pubmed]
  4. Nuf2, a spindle pole body-associated protein required for nuclear division in yeast. Osborne, M.A., Schlenstedt, G., Jinks, T., Silver, P.A. J. Cell Biol. (1994) [Pubmed]
  5. Role of transcription factor Kar4 in regulating downstream events in the Saccharomyces cerevisiae pheromone response pathway. Lahav, R., Gammie, A., Tavazoie, S., Rose, M.D. Mol. Cell. Biol. (2007) [Pubmed]
  6. Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Kurihara, L.J., Stewart, B.G., Gammie, A.E., Rose, M.D. Mol. Cell. Biol. (1996) [Pubmed]
  7. The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Shanks, R.M., Kamieniecki, R.J., Dawson, D.S. Genetics (2001) [Pubmed]
  8. Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. Page, B.D., Satterwhite, L.L., Rose, M.D., Snyder, M. J. Cell Biol. (1994) [Pubmed]
  9. The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Barrett, J.G., Manning, B.D., Snyder, M. Mol. Biol. Cell (2000) [Pubmed]
  10. The Rho-GEF Rom2p localizes to sites of polarized cell growth and participates in cytoskeletal functions in Saccharomyces cerevisiae. Manning, B.D., Padmanabha, R., Snyder, M. Mol. Biol. Cell (1997) [Pubmed]
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