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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDC1  -  Ddc1p

Saccharomyces cerevisiae S288c

Synonyms: DNA damage checkpoint protein 1, YPL194W
 
 
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High impact information on DDC1

  • The DDC1 gene was identified, together with MEC3 and other checkpoint genes, during a screening for mutations causing synthetic lethality when combined with a conditional allele altering DNA primase [1].
  • Therefore, DDC1 is involved in all the known DNA damage checkpoints [1].
  • Deletion of DDC1 causes sensitivity to UV radiation, methyl methanesulfonate (MMS) and hydroxyurea (HU). ddc1Delta mutants are defective in delaying G1-S and G2-M transition and in slowing down the rate of DNA synthesis when DNA is damaged during G1, G2 or S phase, respectively [1].
  • Conversely, Ddc1p is not required for delaying entry into mitosis when DNA synthesis is inhibited. ddc1 and mec3 mutants belong to the same epistasis group, and DDC1 overexpression can partially suppress MMS and HU sensitivity of mec3Delta strains, as well as their checkpoint defects [1].
  • DDC1 overexpression can partially suppress the phenotypes of the rad24Delta mutation: sensitivity to DNA damage, defect in the DNA damage checkpoint and decrease in DNA damage-induced phosphorylation of Rad53 [2].
 

Other interactions of DDC1

References

  1. The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. Longhese, M.P., Paciotti, V., Fraschini, R., Zaccarini, R., Plevani, P., Lucchini, G. EMBO J. (1997) [Pubmed]
  2. Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Kondo, T., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (1999) [Pubmed]
  3. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Wang, H., Elledge, S.J. Genetics (2002) [Pubmed]
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