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Gene Review

DPB11  -  Dpb11p

Saccharomyces cerevisiae S288c

Synonyms: DNA replication regulator DPB11, J0918, YJL090C
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High impact information on DPB11


Biological context of DPB11


Associations of DPB11 with chemical compounds


Physical interactions of DPB11


Regulatory relationships of DPB11

  • We demonstrate that Dpb11 directly activates the Mec1 kinase in phosphorylating the downstream effector kinase Rad53 (human Chk1/2) and DNA bound RPA [9].

Other interactions of DPB11


Analytical, diagnostic and therapeutic context of DPB11


  1. S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast. Masumoto, H., Muramatsu, S., Kamimura, Y., Araki, H. Nature (2002) [Pubmed]
  2. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Takayama, Y., Kamimura, Y., Okawa, M., Muramatsu, S., Sugino, A., Araki, H. Genes Dev. (2003) [Pubmed]
  3. A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11. Tak, Y.S., Tanaka, Y., Endo, S., Kamimura, Y., Araki, H. EMBO J. (2006) [Pubmed]
  4. DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae. Wang, H., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint. Araki, H., Leem, S.H., Phongdara, A., Sugino, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Wang, H., Elledge, S.J. Genetics (2002) [Pubmed]
  7. Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair. Ogiwara, H., Ui, A., Onoda, F., Tada, S., Enomoto, T., Seki, M. Nucleic Acids Res. (2006) [Pubmed]
  8. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Kamimura, Y., Masumoto, H., Sugino, A., Araki, H. Mol. Cell. Biol. (1998) [Pubmed]
  9. Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. Navadgi-Patil, V.M., Burgers, P.M. J. Biol. Chem. (2008) [Pubmed]
  10. CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast. Tanaka, S., Umemori, T., Hirai, K., Muramatsu, S., Kamimura, Y., Araki, H. Nature (2007) [Pubmed]
  11. CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage. Reid, R.J., Fiorani, P., Sugawara, M., Bjornsti, M.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
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