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Gene Review:

GUP2 - Gup2p

Saccharomyces cerevisiae S288c

Synonyms: Glycerol uptake protein 2, YPL189W

Oliveira, R. et al., Neves, L. et al., Holst, B. et al.

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High impact information on GUP2

GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae [1].
Furthermore, transcription of GUP1 and GUP2 was not affected in the gpd1gpd2 mutant strain grown under salt stress in the presence of small amounts of glycerol, in which case a very high Vmax of glycerol uptake was reported [2].

Biological context of GUP2

Previous studies evidenced in Saccharomyces cerevisiae the activity of a H(+)/glycerol symport, derepressed by growth on non-fermentable carbon sources, later associated with GUP1 and GUP2 genes [3].
Expression studies of GUP1 and GUP2, genes involved in glycerol active transport in Saccharomyces cerevisiae, using semi-quantitative RT-PCR [2].

Associations of GUP2 with chemical compounds

GUP1 and GUP2 were identified and characterised as genes involved in glycerol active uptake [2].

Analytical, diagnostic and therapeutic context of GUP2

Using semi-quantitative RT-PCR, GUP1 and GUP2 transcription was measured [2].

References

GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Holst, B., Lunde, C., Lages, F., Oliveira, R., Lucas, C., Kielland-Brandt, M.C. Mol. Microbiol. (2000) [Pubmed]
Expression studies of GUP1 and GUP2, genes involved in glycerol active transport in Saccharomyces cerevisiae, using semi-quantitative RT-PCR. Oliveira, R., Lucas, C. Curr. Genet. (2004) [Pubmed]
New insights on glycerol transport in Saccharomyces cerevisiae. Neves, L., Lages, F., Lucas, C. FEBS Lett. (2004) [Pubmed]

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