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Gene Review

GUP1  -  Gup1p

Saccharomyces cerevisiae S288c

Synonyms: Glycerol uptake protein 1, YGL084C
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High impact information on GUP1


Biological context of GUP1


Anatomical context of GUP1


Associations of GUP1 with chemical compounds

  • These results suggest different roles for Gup1/2p than glycerol transport [5].
  • Eadie-Hofstee plots of glycerol uptake in wild-type Saccharomyces cerevisiae W303-1A grown on glucose showed the presence of both saturable transport and simple diffusion, whereas an fps1delta mutant displayed only simple diffusion [10].
  • In contrast, the phenylalanine residue, which is believed to position substrates near the conserved arginine, was not required for either arsenic trioxide or glycerol uptake [11].
  • From these results, it is suggested that DL1 has distinct metabolic characteristics including enhanced metabolic activities both in glycerol uptake and the glyoxylate bypass cycle, as compared to A16 [12].

Analytical, diagnostic and therapeutic context of GUP1

  • Using semi-quantitative RT-PCR, GUP1 and GUP2 transcription was measured [6].
  • The subcellular localization and functional expression of biologically active Gup1-GFP chimaeras was monitored by confocal laser scanning and electron microscopy, thus supplying the first study of GUP1 dynamics in live yeast cells [7].


  1. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. Luyten, K., Albertyn, J., Skibbe, W.F., Prior, B.A., Ramos, J., Thevelein, J.M., Hohmann, S. EMBO J. (1995) [Pubmed]
  2. GUP1 of Saccharomyces cerevisiae encodes an O-acyltransferase involved in remodeling of the GPI anchor. Bosson, R., Jaquenoud, M., Conzelmann, A. Mol. Biol. Cell (2006) [Pubmed]
  3. A member of the sugar transporter family, Stl1p is the glycerol/H+ symporter in Saccharomyces cerevisiae. Ferreira, C., van Voorst, F., Martins, A., Neves, L., Oliveira, R., Kielland-Brandt, M.C., Lucas, C., Brandt, A. Mol. Biol. Cell (2005) [Pubmed]
  4. GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Holst, B., Lunde, C., Lages, F., Oliveira, R., Lucas, C., Kielland-Brandt, M.C. Mol. Microbiol. (2000) [Pubmed]
  5. New insights on glycerol transport in Saccharomyces cerevisiae. Neves, L., Lages, F., Lucas, C. FEBS Lett. (2004) [Pubmed]
  6. Expression studies of GUP1 and GUP2, genes involved in glycerol active transport in Saccharomyces cerevisiae, using semi-quantitative RT-PCR. Oliveira, R., Lucas, C. Curr. Genet. (2004) [Pubmed]
  7. Subcellular localization and functional expression of the glycerol uptake protein 1 (GUP1) of Saccharomyces cerevisiae tagged with green fluorescent protein. Bleve, G., Zacheo, G., Cappello, M.S., Dellaglio, F., Grieco, F. Biochem. J. (2005) [Pubmed]
  8. Water transport across yeast vacuolar and plasma membrane-targeted secretory vesicles occurs by passive diffusion. Coury, L.A., Hiller, M., Mathai, J.C., Jones, E.W., Zeidel, M.L., Brodsky, J.L. J. Bacteriol. (1999) [Pubmed]
  9. Absence of Gup1p in Saccharomyces cerevisiae results in defective cell wall composition, assembly, stability and morphology. Ferreira, C., Silva, S., van Voorst, F., Aguiar, C., Kielland-Brandt, M.C., Brandt, A., Lucas, C. FEMS Yeast Res. (2006) [Pubmed]
  10. Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae. Sutherland, F.C., Lages, F., Lucas, C., Luyten, K., Albertyn, J., Hohmann, S., Prior, B.A., Kilian, S.G. J. Bacteriol. (1997) [Pubmed]
  11. Arsenic trioxide uptake by human and rat aquaglyceroporins. Liu, Z., Carbrey, J.M., Agre, P., Rosen, B.P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Comparative proteome analysis of Hansenula polymorpha DL1 and A16. Kim, Y.H., Han, K.Y., Lee, K., Heo, J.H., Kang, H.A., Lee, J. Proteomics (2004) [Pubmed]
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