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Gene Review:

CBC2 - Cbc2p

Saccharomyces cerevisiae S288c

Synonyms: 20 kDa nuclear cap-binding protein, CBP20, MUD13, NCBP 20 kDa subunit, Nuclear cap-binding protein subunit 2, ...

Shen, E.C. et al., McKee, A.H. et al., Lall, S. et al.

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High impact information on CBC2

In contrast we find that nuclear cap binding proteins (CBP-20 and 80), eIF4G, and PAB-1 are absolutely required for development [1].
Deletion of CBP80 or CBP20 in combination with certain temperature-sensitive npl3 mutant alleles fail to grow and thus display a synthetic lethal relationship [2].
In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20) [2].
Two new meiosis-specific genes, SAE1 and SAE3, have been identified in a screen for mutations that confer an intermediate block in meiotic prophase [3].

Biological context of CBC2

Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3 [3].

References

Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis. Lall, S., Piano, F., Davis, R.E. Mol. Biol. Cell (2005) [Pubmed]
7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. Shen, E.C., Stage-Zimmermann, T., Chui, P., Silver, P.A. J. Biol. Chem. (2000) [Pubmed]
Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis-specific genes SAE1 and SAE3. McKee, A.H., Kleckner, N. Genetics (1997) [Pubmed]

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NCBP2_ANOGA	Anopheles gambiae str. PEST
AGOS_AFL050W	Ashbya gossypii ATCC 10895
ncbp-2	Caenorhabditis elegans
Cbp20	Drosophila melanogaster
LOC422214	Gallus gallus
KLLA0B10472g	Kluyveromyces lactis NRRL Y-1140
MGG_06296	Magnaporthe oryzae 70-15
NCU00210	Neurospora crassa OR74A
SPBC13A2.01c	Schizosaccharomyces pombe 972h-

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