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Gene Review

STO1  -  Sto1p

Saccharomyces cerevisiae S288c

Synonyms: 80 kDa nuclear cap-binding protein, CBC1, CBP80, GCR3, Glycolysis regulation protein 3, ...
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High impact information on STO1

  • Furthermore, we find a genetic relationship between Hmt1p and cap-binding protein 80 (CBP80) [1].
  • This conclusion was corroborated by finding an inverse relationship of the CBC1 and SKS1 mRNA levels in normal strains grown under different conditions [2].
  • Microarray procedures were used to determine the half-lives of mRNAs from normal and mutant strains, leading to the tentative identification of hundreds of normal mRNAs that were notably stabilized when either CBC1 or RRP6 were deleted [2].
  • In this report, we define a genetic relationship between NPL3 and the nonessential genes encoding the subunits of the cap-binding complex (CBP80 and CBP20) [3].
  • Further analysis showed that gcr3 mutations also suppressed the temperature-sensitive growth of hpr1 single mutants [4].

Biological context of STO1

  • Plasmid DNA isolated from gcr3 mutants was significantly more negatively supercoiled than normal, suggesting that Gcr3 protein, like topoisomerase I and Hpr1p, affects chromatin structure, perhaps during transcription [4].
  • The GCR3 gene was obtained by growth complementation from a genomic DNA library, and the complemented strains had normal enzyme levels [5].
  • The recessive single nuclear gene mutation, named gcr3, caused an extremely defective growth phenotype on fermentable carbon sources such as glucose, while growth on respiratory media was almost normal [5].

Associations of STO1 with chemical compounds

  • Interestingly, the sto1-delta deletion mutant stopped growing earlier than the parent and produced 20% more ethanol from xylose [6].

Regulatory relationships of STO1

  • The fact that top1 suppressed the growth defect of gcr3 suggested an interaction between those two genes also [4].

Other interactions of STO1

  • Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants [4].

Analytical, diagnostic and therapeutic context of STO1

  • The resulting sto1-delta deletion mutant, FPL-Shi31, did not contain other isoforms of Sto protein that were detectable by Western blot analysis using an alternative oxidase monoclonal antibody raised against the Sto protein from Sauromatum guttatum [6].


  1. Arginine methylation facilitates the nuclear export of hnRNP proteins. Shen, E.C., Henry, M.F., Weiss, V.H., Valentini, S.R., Silver, P.A., Lee, M.S. Genes Dev. (1998) [Pubmed]
  2. A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae. Kuai, L., Das, B., Sherman, F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. 7The yeast mRNA-binding protein Npl3p interacts with the cap-binding complex. Shen, E.C., Stage-Zimmermann, T., Chui, P., Silver, P.A. J. Biol. Chem. (2000) [Pubmed]
  4. Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants. Uemura, H., Pandit, S., Jigami, Y., Sternglanz, R. Genetics (1996) [Pubmed]
  5. GCR3 encodes an acidic protein that is required for expression of glycolytic genes in Saccharomyces cerevisiae. Uemura, H., Jigami, Y. J. Bacteriol. (1992) [Pubmed]
  6. SHAM-sensitive alternative respiration in the xylose-metabolizing yeast Pichia stipitis. Shi, N.Q., Cruz, J., Sherman, F., Jeffries, T.W. Yeast (2002) [Pubmed]
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